ID   SYF1_CANGA              Reviewed;         835 AA.
AC   Q6FUJ7;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Pre-mRNA-splicing factor SYF1;
GN   Name=SYF1; OrderedLocusNames=CAGL0F02915g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CR380952; CAG59021.1; -; Genomic_DNA.
DR   RefSeq; XP_446097.1; XM_446097.1.
DR   AlphaFoldDB; Q6FUJ7; -.
DR   SMR; Q6FUJ7; -.
DR   STRING; 5478.XP_446097.1; -.
DR   EnsemblFungi; CAG59021; CAG59021; CAGL0F02915g.
DR   GeneID; 2887745; -.
DR   KEGG; cgr:CAGL0F02915g; -.
DR   CGD; CAL0129874; CAGL0F02915g.
DR   VEuPathDB; FungiDB:CAGL0F02915g; -.
DR   eggNOG; KOG2047; Eukaryota.
DR   HOGENOM; CLU_007736_0_0_1; -.
DR   InParanoid; Q6FUJ7; -.
DR   OMA; FLMQQPL; -.
DR   Proteomes; UP000002428; Chromosome F.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IEA:EnsemblFungi.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00386; HAT; 8.
DR   SUPFAM; SSF48452; SSF48452; 3.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..835
FT                   /note="Pre-mRNA-splicing factor SYF1"
FT                   /id="PRO_0000205727"
FT   REPEAT          7..38
FT                   /note="HAT 1"
FT   REPEAT          46..77
FT                   /note="HAT 2"
FT   REPEAT          313..348
FT                   /note="HAT 3"
FT   REPEAT          414..456
FT                   /note="HAT 4"
FT   REPEAT          458..494
FT                   /note="HAT 5"
FT   REPEAT          517..551
FT                   /note="HAT 6"
FT   REPEAT          589..623
FT                   /note="HAT 7"
FT   REPEAT          628..664
FT                   /note="HAT 8"
FT   REPEAT          707..741
FT                   /note="HAT 9"
FT   REPEAT          743..777
FT                   /note="HAT 10"
SQ   SEQUENCE   835 AA;  98986 MW;  A740D838E526176A CRC64;
     MADIDQYILD DSDIAFEYEL QKSPSVEVWQ RYIAHWEAQV CEDGVRSARH ILWLYERMVT
     QFPTLTVWEQ YIGWFRRQYK LDQYLDTFKL YERCINSVKG PLGVFAVEVM LFCISTFDLD
     IIMKGLQLVL HRCNKDEVER IWNIVLGFAL EHVLPSEEGP NNIDFSAFND RNYEDLRLDI
     YKLLFLGGDQ TEIEDDEEDE DVDKWTASLL RYYLQVANED KYDETLRLLI RTKDIKIIKE
     CFDLYIFNDK TGKNNRESKK EYDFDLYIYY LDTLDKLRLD KDYKSVFDNL LEKYPQHRVL
     LTLKLADFHM KRADFDKMEK VLTKALSETV KTNEFIAIYT YHVNFEQAYV ETIFDEMRDD
     PEIQVQKKWK SEMDDHLIIL GDLTSRYHLL VNDLKIRQNP NSVSNWLERT TLFEDFDKKC
     EVFVEAIKTI DPIKVKDKEY GMLGKLWCDY AKVYWSNKSY EEARTIYESA TKVPFPDLQD
     LEIVWHTWAV NEFQIHNIER ALKILRKALT VPPSYESIID RFKSENRRLP SQTILFTSKR
     LWNYYIDLLE SIPTIDANDV IRAYDTLMTL KLITPVGILN YATFLKQNNN LHGSLQVYEK
     GINMFPPEIC YELWTLLLDE VMEPAHQATK ERIRELFEQC LQQLGNTDIN INSIYVKYSD
     FEIHNKLFSR AIDLLMSGAR RPYTNKEQLK QRVDLWESAI SKCEEFLGPD SLRQLLSECI
     QELPNSKAIT YVLKFTKLEM SLSDYTRARE LLQYGAQLLP PIKNEELWGL WEQFELEHGD
     KSYYKEMLLL KQKLEKEMKV DTEEVSKGQG NVQFVASSVK NQEAKTNPDE IEIDI