ID   SYF1_CRYNB              Reviewed;        1031 AA.
AC   P0CO09; Q55SQ9; Q5KH46;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Pre-mRNA-splicing factor SYF1;
GN   Name=SYF1; OrderedLocusNames=CNBE1250;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; AAEY01000024; EAL20762.1; -; Genomic_DNA.
DR   RefSeq; XP_775409.1; XM_770316.1.
DR   AlphaFoldDB; P0CO09; -.
DR   SMR; P0CO09; -.
DR   PRIDE; P0CO09; -.
DR   EnsemblFungi; AAW43409; AAW43409; CNE01310.
DR   EnsemblFungi; EAL20762; EAL20762; CNBE1250.
DR   GeneID; 4936133; -.
DR   KEGG; cnb:CNBE1250; -.
DR   VEuPathDB; FungiDB:CNBE1250; -.
DR   HOGENOM; CLU_007736_1_0_1; -.
DR   Proteomes; UP000001435; Chromosome 5.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 4.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   SMART; SM00386; HAT; 10.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 3.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Repeat; Spliceosome.
FT   CHAIN           1..1031
FT                   /note="Pre-mRNA-splicing factor SYF1"
FT                   /id="PRO_0000410109"
FT   REPEAT          28..60
FT                   /note="HAT 1"
FT   REPEAT          90..122
FT                   /note="HAT 2"
FT   REPEAT          214..248
FT                   /note="HAT 3"
FT   REPEAT          250..269
FT                   /note="HAT 4"
FT   REPEAT          452..487
FT                   /note="HAT 5"
FT   REPEAT          610..646
FT                   /note="HAT 6"
FT   REPEAT          664..698
FT                   /note="HAT 7"
FT   REPEAT          700..732
FT                   /note="HAT 8"
FT   REPEAT          734..768
FT                   /note="HAT 9"
FT   REPEAT          773..807
FT                   /note="HAT 10"
FT   REPEAT          845..879
FT                   /note="HAT 11"
FT   REPEAT          881..915
FT                   /note="HAT 12"
FT   REGION          346..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          948..969
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1003..1031
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        948..965
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1031 AA;  117163 MW;  7F98779701D99C67 CRC64;
     MASTSLVDSL TSHFPLTLPI PTPITHPHLI PSADLPVEED LLHNPENLRS WLSYIHNVKE
     KIAADEPAKG GVLSPEEEIL GPLASKNARD GLQRLVSIYE RAIAVFPTSY KLWKAYYLTR
     QSYVLGELTN DAKEARSQQA KRGAAYKTNV RELLDGAEEA HEWTGGLDPV VGYAEWRSLV
     ATGERMIMCL PNLPIPWLLH LGVLLHPKCP SVFKNGSYAR RAFDRALRTL PPSLHGRVWG
     LYLRWAEIVG GDAGERVWRR YLKVDPSLTE RHITYLLEAE EPRPLAAAKY LLSIARRAQQ
     NLYSSLEGKS PYQLFVDFLE LVEKYADQIG MDEEGTLELQ RTKRAVEEKV DGEQPQVEGQ
     EQQPQEEPAS INGRLMRIAG PPVPLEQGKL FKPVNAASAQ APTQLTYDED TDPSNPRLLD
     VEGIVERDGL QVYKDQAGRL WTGLATYWIK RGEFERATAT FERGLAAVVT IRDFTQIFDA
     YAEFSETMIS TLMDALADED NLEDEDFDAE ETEQELDERM KSFEELMDRR PFLVNDVLLR
     RNPNEVVEWE KRIALHGDDD AKVVEAYVKA LDTINPRKAT GPLYPLYVNF AKFYEEGGSK
     DDNGEPRNEP DLEQARKIFE RATKVPFKAV DELAEVWCEW AEMELRNENY EEAIRLMQRA
     TTVPKNTKIN YYDDNIPPQS RLFKSLKLWS YYSDLEESIG TVESTKAVYD KIMELKIANA
     QVIVNYATFL EENKYFEESF KVYERGIELF HFPIAFEIWN IYLSKFVKRY GGKKLERARD
     LFEQALENCP EKFCKPLYLM YAKLEEEHGL AKRAMGIYDR AASTVQDSDK FEMYTIYIAK
     ATANFGLPAT RPIYERALES LPDKQTAEMC RRFARMERKL GEIDRARAIY AHASQFCDPR
     IEPEFWQEWN DFEIETGSED TFREMLRIKR AVQASFNTET SFIAAQAAAA SKGTEKPTDT
     SAQEAQDAAD PMAAMERELS AAGADGARKG GAPAFVASTL NKTNANGIDE GGEETGEMAN
     PDAIVMDEDE F