SYF1_CRYNJ
ID SYF1_CRYNJ Reviewed; 1031 AA.
AC P0CO08; Q55SQ9; Q5KH46;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Pre-mRNA-splicing factor SYF1;
GN Name=SYF1; OrderedLocusNames=CNE01310;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR EMBL; AE017345; AAW43409.1; -; Genomic_DNA.
DR RefSeq; XP_570716.1; XM_570716.1.
DR AlphaFoldDB; P0CO08; -.
DR SMR; P0CO08; -.
DR STRING; 5207.AAW43409; -.
DR PaxDb; P0CO08; -.
DR EnsemblFungi; AAW43409; AAW43409; CNE01310.
DR GeneID; 3257860; -.
DR KEGG; cne:CNE01310; -.
DR VEuPathDB; FungiDB:CNE01310; -.
DR eggNOG; KOG2047; Eukaryota.
DR HOGENOM; CLU_007736_1_0_1; -.
DR InParanoid; P0CO08; -.
DR OMA; AWHARAK; -.
DR OrthoDB; 370051at2759; -.
DR Proteomes; UP000002149; Chromosome 5.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR SMART; SM00386; HAT; 10.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 3.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..1031
FT /note="Pre-mRNA-splicing factor SYF1"
FT /id="PRO_0000205728"
FT REPEAT 28..60
FT /note="HAT 1"
FT REPEAT 90..122
FT /note="HAT 2"
FT REPEAT 214..248
FT /note="HAT 3"
FT REPEAT 250..269
FT /note="HAT 4"
FT REPEAT 452..487
FT /note="HAT 5"
FT REPEAT 610..646
FT /note="HAT 6"
FT REPEAT 664..698
FT /note="HAT 7"
FT REPEAT 700..732
FT /note="HAT 8"
FT REPEAT 734..768
FT /note="HAT 9"
FT REPEAT 773..807
FT /note="HAT 10"
FT REPEAT 845..879
FT /note="HAT 11"
FT REPEAT 881..915
FT /note="HAT 12"
FT REGION 346..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1031 AA; 117163 MW; 7F98779701D99C67 CRC64;
MASTSLVDSL TSHFPLTLPI PTPITHPHLI PSADLPVEED LLHNPENLRS WLSYIHNVKE
KIAADEPAKG GVLSPEEEIL GPLASKNARD GLQRLVSIYE RAIAVFPTSY KLWKAYYLTR
QSYVLGELTN DAKEARSQQA KRGAAYKTNV RELLDGAEEA HEWTGGLDPV VGYAEWRSLV
ATGERMIMCL PNLPIPWLLH LGVLLHPKCP SVFKNGSYAR RAFDRALRTL PPSLHGRVWG
LYLRWAEIVG GDAGERVWRR YLKVDPSLTE RHITYLLEAE EPRPLAAAKY LLSIARRAQQ
NLYSSLEGKS PYQLFVDFLE LVEKYADQIG MDEEGTLELQ RTKRAVEEKV DGEQPQVEGQ
EQQPQEEPAS INGRLMRIAG PPVPLEQGKL FKPVNAASAQ APTQLTYDED TDPSNPRLLD
VEGIVERDGL QVYKDQAGRL WTGLATYWIK RGEFERATAT FERGLAAVVT IRDFTQIFDA
YAEFSETMIS TLMDALADED NLEDEDFDAE ETEQELDERM KSFEELMDRR PFLVNDVLLR
RNPNEVVEWE KRIALHGDDD AKVVEAYVKA LDTINPRKAT GPLYPLYVNF AKFYEEGGSK
DDNGEPRNEP DLEQARKIFE RATKVPFKAV DELAEVWCEW AEMELRNENY EEAIRLMQRA
TTVPKNTKIN YYDDNIPPQS RLFKSLKLWS YYSDLEESIG TVESTKAVYD KIMELKIANA
QVIVNYATFL EENKYFEESF KVYERGIELF HFPIAFEIWN IYLSKFVKRY GGKKLERARD
LFEQALENCP EKFCKPLYLM YAKLEEEHGL AKRAMGIYDR AASTVQDSDK FEMYTIYIAK
ATANFGLPAT RPIYERALES LPDKQTAEMC RRFARMERKL GEIDRARAIY AHASQFCDPR
IEPEFWQEWN DFEIETGSED TFREMLRIKR AVQASFNTET SFIAAQAAAA SKGTEKPTDT
SAQEAQDAAD PMAAMERELS AAGADGARKG GAPAFVASTL NKTNANGIDE GGEETGEMAN
PDAIVMDEDE F
