ID   SYF1_DEBHA              Reviewed;         850 AA.
AC   Q6BQ23;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Pre-mRNA-splicing factor SYF1;
GN   Name=SYF1; OrderedLocusNames=DEHA2E08954g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CR382137; CAG87933.2; -; Genomic_DNA.
DR   RefSeq; XP_459697.2; XM_459697.1.
DR   AlphaFoldDB; Q6BQ23; -.
DR   STRING; 4959.XP_459697.2; -.
DR   EnsemblFungi; CAG87933; CAG87933; DEHA2E08954g.
DR   GeneID; 2902957; -.
DR   KEGG; dha:DEHA2E08954g; -.
DR   VEuPathDB; FungiDB:DEHA2E08954g; -.
DR   eggNOG; KOG2047; Eukaryota.
DR   HOGENOM; CLU_007736_3_0_1; -.
DR   InParanoid; Q6BQ23; -.
DR   OMA; YWRLWES; -.
DR   OrthoDB; 370051at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 4.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   SMART; SM00386; HAT; 10.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..850
FT                   /note="Pre-mRNA-splicing factor SYF1"
FT                   /id="PRO_0000205729"
FT   REPEAT          10..42
FT                   /note="HAT 1"
FT   REPEAT          46..78
FT                   /note="HAT 2"
FT   REPEAT          90..122
FT                   /note="HAT 3"
FT   REPEAT          126..160
FT                   /note="HAT 4"
FT   REPEAT          208..247
FT                   /note="HAT 5"
FT   REPEAT          408..442
FT                   /note="HAT 6"
FT   REPEAT          444..480
FT                   /note="HAT 7"
FT   REPEAT          500..531
FT                   /note="HAT 8"
FT   REPEAT          574..609
FT                   /note="HAT 9"
FT   REPEAT          612..653
FT                   /note="HAT 10"
FT   REPEAT          708..744
FT                   /note="HAT 11"
FT   REPEAT          746..782
FT                   /note="HAT 12"
SQ   SEQUENCE   850 AA;  100241 MW;  17E21318BA375867 CRC64;
     MSGSVWDIEG LLCEDDIPYE QEVAKNPNNL SNWLRYYRFK SSTSSCTFQN RVFILERAVK
     QLPRSYKLWM IYIDVVLQEV QTSVSYKSKS EILSVNMVFE RSLQLLNRAP ILWIKYLEFL
     VETQPYEITL LRRKFNECLY NLPISQHHLI WPLYIRFADD VGGMTGVKVY LKYLQYANPE
     SLQGLNNEQE GELGITIDDI ISKLVEFGDV KEASKLFQHI LQHTDKFIGL SKSPLQLWIE
     YIDLLVNSVS KNKRSTVNYN EFDYFFEKLI KDGLQKFPDQ IGKFYLKLTF YFIKRKNLFK
     ARYYFDEGLK TCVSVKDFTM IFDSYTEFEE NILTNMSEKL EKLGEDSDLN NELDLRMNVF
     EKLINDRPYL LNDMMLRQDV NNLDEWFKKI VLYKKDSDIN MMLDTYAAAL RTINPLKAHS
     LANKKENTLP NLWINYANVY ASQNDVKTAN LIFSKSVKSQ FQSPDDLATL YIEWCELFVK
     HNDDKKAIEI VEDICTSERG KFDYNDSSID IHIRVQKSIK LWSFYLDLLE SMIENNNQID
     EIEKVINAYN ITIDLKIATP LTIINFANFL EEWNFYERSF SAYEMGLKIF KDSKIKFEIW
     NIYLSKIIKH ELNIERIRDL FEQCLNESSI EGYNGCPANL CKPVYLLYSQ YEQSKGWFTK
     SVKILQQGLS KLDDGYNQEF YTKAEKDTIL RDKFDIYQVL ISKILKLNDH NETRKIYEQS
     LKDNQLTLPN LIQLTMEFIN FETELMEFNR VRSLFKYVCQ LSNPQSPLIE PIWHNWETFE
     LNHGNEATFK DMLRFKRKIV TEFEKDIILK NSLNPMGFVK SSQGPKVSSI AISAPKEENN
     PDSIDLDMDM