ID   SYF1_DICDI              Reviewed;         850 AA.
AC   Q54Z08;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Pre-mRNA-splicing factor SYF1;
DE   AltName: Full=Protein XAB2 homolog;
GN   Name=xab2; Synonyms=syf1; ORFNames=DDB_G0277977;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC       spliceosome. Involved in transcription-coupled repair (TCR),
CC       transcription and pre-mRNA splicing. {ECO:0000250|UniProtKB:Q9HCS7}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex.
CC       {ECO:0000250|UniProtKB:Q9HCS7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99PK0}.
CC       Note=Detected in the splicing complex carrying pre-mRNA.
CC       {ECO:0000250|UniProtKB:Q99PK0}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAL68161.1; -; Genomic_DNA.
DR   RefSeq; XP_642044.1; XM_636952.1.
DR   AlphaFoldDB; Q54Z08; -.
DR   SMR; Q54Z08; -.
DR   STRING; 44689.DDB0233461; -.
DR   PaxDb; Q54Z08; -.
DR   EnsemblProtists; EAL68161; EAL68161; DDB_G0277977.
DR   GeneID; 8621256; -.
DR   KEGG; ddi:DDB_G0277977; -.
DR   dictyBase; DDB_G0277977; xab2.
DR   eggNOG; KOG2047; Eukaryota.
DR   HOGENOM; CLU_007736_0_0_1; -.
DR   InParanoid; Q54Z08; -.
DR   OMA; FLMQQPL; -.
DR   PhylomeDB; Q54Z08; -.
DR   Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR   Reactome; R-DDI-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q54Z08; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 5.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   SMART; SM00386; HAT; 10.
DR   SUPFAM; SSF48452; SSF48452; 6.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome; Transcription.
FT   CHAIN           1..850
FT                   /note="Pre-mRNA-splicing factor SYF1"
FT                   /id="PRO_0000328142"
FT   REPEAT          25..57
FT                   /note="HAT 1"
FT   REPEAT          58..90
FT                   /note="HAT 2"
FT   REPEAT          100..132
FT                   /note="HAT 3"
FT   REPEAT          134..168
FT                   /note="HAT 4"
FT   REPEAT          171..203
FT                   /note="HAT 5"
FT   REPEAT          281..316
FT                   /note="HAT 6"
FT   REPEAT          477..509
FT                   /note="HAT 7"
FT   REPEAT          511..543
FT                   /note="HAT 8"
FT   REPEAT          545..579
FT                   /note="HAT 9"
FT   REPEAT          584..618
FT                   /note="HAT 10"
FT   REPEAT          692..726
FT                   /note="HAT 11"
FT   REGION          761..837
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        773..812
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        821..836
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   850 AA;  101312 MW;  031FDA89110C2A6D CRC64;
     MPSINENEDI INKLKMSTIT DDIIIQPSID DLPYEEDVSK NPYSVNCWLR YLEFKQGSPQ
     KQRNYIYERA IRELPRSYKI WHQYLLERTL AIRGKCILEN SFEAVNTLFE RSLVFLDKMP
     RIWIEYCEFL MIQEKITLTR KTFDRALIAL PVTQHYRIWN EYTKFILKRS IPSLTCIRVY
     KRYLKIQPEK VEEYIEYLIK IKEWQEVVNQ LIKLLDNVKF KSIKGKSRHD HWLQLCEILS
     SYPKQITGVD VDSVIRSGIG KFSDQIGKLW CYLSDYYIQL AQFEKARDIF EEALTSVGTA
     RDFSFIWESY TQFEDSLIAA KQEILEEDPS EDNLLEFDII IERYENLIQR QPLLLNSVML
     KQNPNNVQEW LKRVNLYSNP TPNVKMIIQT FTDSIKSIDP QLAKGKLSTI YSTFAHFYEQ
     NNKLSQARLI FENSLTVNFK TIDDLSTLYC DYAEMELKHR NYEKAIEILK RGTVSPKKQN
     TIIEENEPVQ KRLFKSIKIW TFYVDLEESF GTFHNTKSIY EKMIQLKVVT PQIILNFAKY
     LEENKYFEDM FKAYEHGVQL FLFPHVQDIW ITYLTKFIQR YAGMKLERTR DLFEQVLSKV
     PPKESIIFYL MYANFEEQYG LARHSMAVYD RAAKSVDKED RFKMYLLYIH RASEFFGVNQ
     TREIFSKAIE QLPDQYVRDM CLKFADMEKK YGEIDRARSI YIHGSQFSDP RTSMFYWNTW
     SDFEKLHGNE DTFKEMLRIR RSVQASYITQ NPTLALLNKL NNKDDKDDKN QQQKQQQQQQ
     EKQQQQQQQQ QQASTLTKSK PVTVSLPETI QYNKKIENDD EINLDDDEEE EEEEDQLAIK
     AFPKTLLKII