ID   SYF1_EMENI              Reviewed;         851 AA.
AC   Q5BH69; C8VQL5;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Pre-mRNA-splicing factor syf1;
GN   Name=syf1; ORFNames=AN0111;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; AACD01000004; EAA65289.1; -; Genomic_DNA.
DR   EMBL; BN001308; CBF90179.1; -; Genomic_DNA.
DR   RefSeq; XP_657715.1; XM_652623.1.
DR   AlphaFoldDB; Q5BH69; -.
DR   SMR; Q5BH69; -.
DR   STRING; 162425.CADANIAP00002638; -.
DR   PRIDE; Q5BH69; -.
DR   EnsemblFungi; CBF90179; CBF90179; ANIA_00111.
DR   EnsemblFungi; EAA65289; EAA65289; AN0111.2.
DR   GeneID; 2875887; -.
DR   KEGG; ani:AN0111.2; -.
DR   eggNOG; KOG2047; Eukaryota.
DR   HOGENOM; CLU_007736_0_0_1; -.
DR   InParanoid; Q5BH69; -.
DR   OMA; FLMQQPL; -.
DR   OrthoDB; 370051at2759; -.
DR   Proteomes; UP000000560; Chromosome VIII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 5.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00386; HAT; 11.
DR   SUPFAM; SSF48452; SSF48452; 3.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..851
FT                   /note="Pre-mRNA-splicing factor syf1"
FT                   /id="PRO_0000205730"
FT   REPEAT          12..44
FT                   /note="HAT 1"
FT   REPEAT          63..95
FT                   /note="HAT 2"
FT   REPEAT          107..139
FT                   /note="HAT 3"
FT   REPEAT          141..175
FT                   /note="HAT 4"
FT   REPEAT          291..326
FT                   /note="HAT 5"
FT   REPEAT          398..432
FT                   /note="HAT 6"
FT   REPEAT          434..470
FT                   /note="HAT 7"
FT   REPEAT          487..519
FT                   /note="HAT 8"
FT   REPEAT          558..592
FT                   /note="HAT 9"
FT   REPEAT          595..629
FT                   /note="HAT 10"
FT   REPEAT          667..701
FT                   /note="HAT 11"
FT   REPEAT          703..737
FT                   /note="HAT 12"
FT   REGION          771..793
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          810..851
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   851 AA;  98616 MW;  A1DECCE9303646EF CRC64;
     MDRSSASRPD LYLIADNDSV YEQDLLRNPG TIKPWLAYIE YKQQNGTLYE QAFVGRPLDA
     LIISILNDFQ VMERACKQLP RSYKLWKMYL EFRTKHLKNR NAIKYRAEFQ KVNTLFERAL
     ILLNKMPRIW EMYLTFMLQQ PLVTQTRRTF DRALRALPVT QHNRIWKLYK TFARSASGQT
     AVKIWARYMQ IHPENAEEYI NLLVEMGHYT DAIKRYMEIL DNPRFQSREG KSNFQLWTEM
     VDLLVSKAKK IETGPQTGID VDAILRSGID RFADQRGKLW AGLATYWITK GNFEKARDVF
     EEGITTVMTV RDFTLIFDSY VEFEESIIGS LMEAAAVRAD NGKADEEADF DLDLRMLRFE
     QLMDRRPFLV NDVLLRQNPN NVIEWEKRVA LWGDNNVEIV NTYTAAIAAI NPKKAVGKFS
     ELWVNYAKFY ERGGDLDTAR IIFEKAVKVP FKSVNELAET WCEWAEMELR SENFDKAVEI
     MAKATQAPKK STVDYFDETL SPQQRIHKSW KLWSFYVDLV ESVSSIEETK KVYERIFELR
     IATPQTVVNY ANLLEEHKYF EESFKVYERG LDLFTYPVAF ELWNLYLTKA VDRKIGIERL
     RDLFEQALDG CPPKFARPLY LMYGNLEEER GLARHAMRIY ERATRAVSDE DRFEMFEFYI
     TKSASNFGLP STRPIYERAI AALPDHEAKE MCLKFAEMER RLGEIDRARA IYGHASQFCD
     PRTNAPFWQK WEAFEVQHGN EDTFKEMLRI KRSVQAQYNT DVNFIASQAI ARSQQRAPEG
     EEATAAAERE MDTETTDAMA ALERQARAPI GFVAASTGPE GGNRAPPAGQ GPVAAPANPD
     AIDLDDDMEA D