ID   SYF1_KLULA              Reviewed;         798 AA.
AC   Q6CYA2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Pre-mRNA-splicing factor SYF1;
GN   Name=SYF1; OrderedLocusNames=KLLA0A01969g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH02675.1; -; Genomic_DNA.
DR   RefSeq; XP_451087.1; XM_451087.1.
DR   AlphaFoldDB; Q6CYA2; -.
DR   SMR; Q6CYA2; -.
DR   STRING; 28985.XP_451087.1; -.
DR   EnsemblFungi; CAH02675; CAH02675; KLLA0_A01969g.
DR   GeneID; 2896491; -.
DR   KEGG; kla:KLLA0_A01969g; -.
DR   eggNOG; KOG2047; Eukaryota.
DR   HOGENOM; CLU_007736_0_0_1; -.
DR   InParanoid; Q6CYA2; -.
DR   OMA; FLMQQPL; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   SMART; SM00386; HAT; 9.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..798
FT                   /note="Pre-mRNA-splicing factor SYF1"
FT                   /id="PRO_0000205731"
FT   REPEAT          5..37
FT                   /note="HAT 1"
FT   REPEAT          39..71
FT                   /note="HAT 2"
FT   REPEAT          83..115
FT                   /note="HAT 3"
FT   REPEAT          117..151
FT                   /note="HAT 4"
FT   REPEAT          392..424
FT                   /note="HAT 5"
FT   REPEAT          428..460
FT                   /note="HAT 6"
FT   REPEAT          478..514
FT                   /note="HAT 7"
FT   REPEAT          516..548
FT                   /note="HAT 8"
FT   REPEAT          550..584
FT                   /note="HAT 9"
FT   REPEAT          587..622
FT                   /note="HAT 10"
FT   REPEAT          661..695
FT                   /note="HAT 11"
FT   REPEAT          697..731
FT                   /note="HAT 12"
SQ   SEQUENCE   798 AA;  93271 MW;  7F401598F294D39C CRC64;
     MEIDKFVKEE DIPFEYGVVR ERDNAVSWSR YLATKRSAGD ELNLDWLYER CLKEIKDDWH
     LWKEFLKWRI ELLNDCDIFR HKDEYNKISL LFEQCLTSCG KVGDAWIMYM EWVIQFKDLK
     RIRELLGKAL RSMSWEYHEA IWRVVIDFII NELLIDNKRY ELSLEDSIYY FVHGEHSTNF
     DTDLWSSSIL QRYSLICDDI EPLLIYIFKT HDWSTIVRVF EKHLSPNLKP SQTSLFELYV
     SYITSMILVD NSAGVAAVVD QCIELFPFKK GELKTYLIFN LIRQGKITEA ELYLEKVISE
     TKDIIEFSVL YDFWIRMEEL LTQELIQKMK DDNSEKQRLF ANIRLHADTL TSLIKNHTIR
     LNDLELRREP NNIKLWLERV KLFDTISDKA KVYADAVLTV DYRLQTTPGL LGELWCQYCR
     LFEEDIEKSE VLLDKATNVP FKFLVDLENV WLYWCEYRLK RSIDDAIKVL SVVLEIPDNH
     ELLLQKFEKG ESPAQAAIFS SKRLWAMYLD LLEVKGNYGT AVNAYETAIL IKAATPAMFI
     NYALLNESSG HQAEALAVFE RSVEIFPPSV SKSIWDIYLD VALKADITKE QKRDIFESAI
     KLAASGVACV SFFEKYSDFE LNLGFHERSV EILHKGAKNI SDLESKCTLW EECINRSEKQ
     LDVNHTRKLY EECIETLPNS KAIKFLLPFA ILEESRNEVA RCRALLDYGS KLLKPAQNEE
     LWDFWRNFET MHGTKDSFKN MLKARRFLED TMKVNTEEVS RHADSIEFRA STAKISGSGP
     PSAEDKGYSN TAEIDLGL