SYF1_NEUCR
ID SYF1_NEUCR Reviewed; 829 AA.
AC Q7SAK5;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Pre-mRNA-splicing factor syf1;
DE AltName: Full=mRNA-splicing protein 41;
GN Name=msp-41; Synonyms=syf1; ORFNames=B2E7.050, NCU08036;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR EMBL; BX897675; CAE85536.1; -; Genomic_DNA.
DR EMBL; CM002239; EAA33470.1; -; Genomic_DNA.
DR RefSeq; XP_962706.1; XM_957613.2.
DR AlphaFoldDB; Q7SAK5; -.
DR SMR; Q7SAK5; -.
DR STRING; 5141.EFNCRP00000008259; -.
DR EnsemblFungi; EAA33470; EAA33470; NCU08036.
DR GeneID; 3878813; -.
DR KEGG; ncr:NCU08036; -.
DR VEuPathDB; FungiDB:NCU08036; -.
DR HOGENOM; CLU_007736_0_0_1; -.
DR InParanoid; Q7SAK5; -.
DR OMA; FLMQQPL; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 5.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR SMART; SM00386; HAT; 11.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..829
FT /note="Pre-mRNA-splicing factor syf1"
FT /id="PRO_0000205733"
FT REPEAT 15..47
FT /note="HAT 1"
FT REPEAT 49..81
FT /note="HAT 2"
FT REPEAT 93..125
FT /note="HAT 3"
FT REPEAT 127..161
FT /note="HAT 4"
FT REPEAT 163..182
FT /note="HAT 5"
FT REPEAT 277..312
FT /note="HAT 6"
FT REPEAT 380..418
FT /note="HAT 7"
FT REPEAT 420..456
FT /note="HAT 8"
FT REPEAT 473..505
FT /note="HAT 9"
FT REPEAT 544..578
FT /note="HAT 10"
FT REPEAT 581..615
FT /note="HAT 11"
FT REPEAT 689..723
FT /note="HAT 12"
FT REGION 799..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 96514 MW; 1D021783F7107196 CRC64;
MSILSRVSDR RPDLSLVSEE DFPYEQDIVR NPGSTKPWLA YIEYKLQKGT VQEQAYIMER
ACVQLPRSYK LWKMYLRFRT KHVSKLNAAI FASEYQKVNS LFERALILLN KMPRIWEMYL
KFLMQQPLVT HTRRTFDRAL RALPITQHNR IWALYRPFAN SAEGETAVKI WRRYMQVHPE
DAEDFIELLV AVGLYTEAVH KYIEILNNPR FTSKNSKGHY ELWSEMVDLL VEHATAVETG
HETGIDVERI IRSGIERFAD QRGKLWCGLA TYWIRRGSFE RARDVFEEGI TTVMTVRDFT
LVFDSYTEFE ESIISALMEM ASTRAEKGEV DEVADFDLDI RMMRFEHLMD RRPFLLNDVL
LRQNPNNVTE WEKRVALWGD NKEEVVKTYL DAIEAIQPKK AVGALHQLWT NYAKFYEAGG
DLSSARRIME KAVKVPYKSV AELADMWIEW AEMELRNECF DEAMKVMAKA VQAPKRSTVD
YFDETLSPQQ RVHKSWKLWS FYVDLVESVS SLDETRKVYE RIFELRIATP QTVVNYANLL
EEHKYFEESF KIYERGLDLF SYPVAFELWN LYLTKAVDRK ISIERLRDLF EQAVEDCPPK
FAKVIYLMYG NLEEERGLAR HAMRIYERAT RAVADEDRAD MFNFYITKSA SNFGLPSTRP
IYERAIAALP DAEARDMCLK FADMEKRLGE IDRARAIYGH ASQFCDPRTN PGFWTKWDQF
EVQHGNEDTY KEMLRIKRSV QAQYNTDVNF IASQALARSQ QKRMEEEAAG NGGGEMDAEV
ADAMAQLERQ ARAPVGFVAA SEGPKGGSMP VQPVEVHNPD AIDLDEMDE
