ID   SYF1_USTMA              Reviewed;        1081 AA.
AC   Q4P7S1; A0A0D1DXC2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Pre-mRNA-splicing factor SYF1;
GN   Name=SYF1; ORFNames=UMAG_03842;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CM003149; KIS68261.1; -; Genomic_DNA.
DR   RefSeq; XP_011390275.1; XM_011391973.1.
DR   AlphaFoldDB; Q4P7S1; -.
DR   SMR; Q4P7S1; -.
DR   STRING; 5270.UM03842P0; -.
DR   PRIDE; Q4P7S1; -.
DR   EnsemblFungi; KIS68261; KIS68261; UMAG_03842.
DR   GeneID; 23564190; -.
DR   KEGG; uma:UMAG_03842; -.
DR   VEuPathDB; FungiDB:UMAG_03842; -.
DR   eggNOG; KOG2047; Eukaryota.
DR   HOGENOM; CLU_007736_1_0_1; -.
DR   InParanoid; Q4P7S1; -.
DR   OMA; AWHARAK; -.
DR   OrthoDB; 370051at2759; -.
DR   Proteomes; UP000000561; Chromosome 10.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 4.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   SMART; SM00386; HAT; 13.
DR   SUPFAM; SSF48452; SSF48452; 3.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..1081
FT                   /note="Pre-mRNA-splicing factor SYF1"
FT                   /id="PRO_0000205735"
FT   REPEAT          54..86
FT                   /note="HAT 1"
FT   REPEAT          117..149
FT                   /note="HAT 2"
FT   REPEAT          204..236
FT                   /note="HAT 3"
FT   REPEAT          243..277
FT                   /note="HAT 4"
FT   REPEAT          444..477
FT                   /note="HAT 5"
FT   REPEAT          479..514
FT                   /note="HAT 6"
FT   REPEAT          656..692
FT                   /note="HAT 7"
FT   REPEAT          711..745
FT                   /note="HAT 8"
FT   REPEAT          747..779
FT                   /note="HAT 9"
FT   REPEAT          781..815
FT                   /note="HAT 10"
FT   REPEAT          820..854
FT                   /note="HAT 11"
FT   REPEAT          856..887
FT                   /note="HAT 12"
FT   REPEAT          892..926
FT                   /note="HAT 13"
FT   REPEAT          928..962
FT                   /note="HAT 14"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          526..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1001..1022
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1047..1081
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..542
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1081 AA;  123103 MW;  5DCB6E955E058D2A CRC64;
     MPPKMRSSQE NVAVSSDATI QASSASSPLQ DAMAAVTSLF PLTSPFPDPA KDDTLIPAAD
     ILLEQELLRN PDNFRSWSSY IDHIINTNVV KRPPPDVSLT TYQAALLGPL ASSTQRTALR
     RLTSIYERAL AQFPTRYSLW RDYLQNRSRF VLGDPKGGSD AKRKRDLQAA REKLDFGPTL
     IDSVEDEDFG SAYRGGLDGT VGWQEWKSLA ALYERALMWL PTMPRLWLSY LSMFIHPQCP
     PILSFTHARR TFDRALRTLP GSLHLRVWKV YLKWAERRGG ETCLRVWRRY LRVDPSLTER
     YVSILLAQRE DQDEPEGEEE EAEDDAQSDR SRKQSGSKAL EASKLLLGLA RSAMDGTYVS
     PEGKSPFQLF VEWLELTEKY PEEIGLDPEE EKKYLQHSVA LTSDNGMTNA RRAPRHIQGK
     GTAAREIAKA SSSKHPETDA LDPTRLNVTA IIQKDGLDKF SDQSGRLWTG LATYWIKRGE
     FDVARDTFEA GIQTVKTVRD FTQIFDAYAE TSENVIAFMM DELTEEGGDE EADAEDQEET
     REDKEAELDR RMQEFEELIE RRPLLVNDVL LRRNPDDVQE WEKRVMLYGD NDEKIIETYR
     EAIQKINPRK ATPNFHQLFL NFAQFYEYGG SAGLAKRMAE GVEGQEEEEQ AEQVEGDLES
     ARKIFEKAIT IPFRRVDDLA EIWCEWAEME LRHSNYDEAI RTMARSVAPP RNTKGIQYHD
     DTLPPQTRLF KSLKLWSFYV DLEESLGDVE STKRVYEKML ELKIASAQII INYAAFLEDN
     KYFEESFKVF ERGVELFSYP VAFEIWNVYL SKFVKRYGGA KLERARDLFE QALDKCPARF
     CKPLMLMYGQ LEEEHGLVKR AMKIYERATR AVSTDDRFDM YVFYIAKAAA TFGLAATRPI
     YERAIESLPD RQTAEMCLRF AALERKLGEI DRARVIYAHA SQFCDPRTQT DFWKEWNQFE
     IETGSEDTFR EMLRIKRSVQ AQFNTDVSYI AASALASAQQ NQAQRGAQGS SNGHVREDDV
     DASDPMARVE AASRSAGARQ TAFVAASTAA SGARSADTTI GDVAKNDEVV GGDDQDDQDL
     L