ID   SYF1_YARLI              Reviewed;         736 AA.
AC   Q6CAR6;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Pre-mRNA-splicing factor SYF1;
GN   Name=SYF1; OrderedLocusNames=YALI0D00561g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CR382130; CAG80432.1; -; Genomic_DNA.
DR   RefSeq; XP_502246.1; XM_502246.1.
DR   AlphaFoldDB; Q6CAR6; -.
DR   SMR; Q6CAR6; -.
DR   STRING; 4952.CAG80432; -.
DR   PRIDE; Q6CAR6; -.
DR   EnsemblFungi; CAG80432; CAG80432; YALI0_D00561g.
DR   GeneID; 2910395; -.
DR   KEGG; yli:YALI0D00561g; -.
DR   VEuPathDB; FungiDB:YALI0_D00561g; -.
DR   HOGENOM; CLU_007736_0_0_1; -.
DR   InParanoid; Q6CAR6; -.
DR   OMA; FLMQQPL; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   SMART; SM00386; HAT; 10.
DR   SUPFAM; SSF48452; SSF48452; 5.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..736
FT                   /note="Pre-mRNA-splicing factor SYF1"
FT                   /id="PRO_0000205736"
FT   REPEAT          1..27
FT                   /note="HAT 1"
FT   REPEAT          30..62
FT                   /note="HAT 2"
FT   REPEAT          74..106
FT                   /note="HAT 3"
FT   REPEAT          130..161
FT                   /note="HAT 4"
FT   REPEAT          246..281
FT                   /note="HAT 5"
FT   REPEAT          339..373
FT                   /note="HAT 6"
FT   REPEAT          377..409
FT                   /note="HAT 7"
FT   REPEAT          428..460
FT                   /note="HAT 8"
FT   REPEAT          462..494
FT                   /note="HAT 9"
FT   REPEAT          496..529
FT                   /note="HAT 10"
FT   REPEAT          531..563
FT                   /note="HAT 11"
FT   REPEAT          598..632
FT                   /note="HAT 12"
FT   REPEAT          634..667
FT                   /note="HAT 13"
SQ   SEQUENCE   736 AA;  84663 MW;  54C74B006D7E7166 CRC64;
     MSQHELDIAS SPGDVRPWIR YISSVKNDKT TARQKCILFE RAVTALPRSY KLWKEYLDFR
     SGLCTGLNPI KHADEYDRVN ALYEKSLVLL HKMPVIWLQY LQFLMLQPKV TKTRSVINEA
     LRSLPVQQHP RVLKLALQFG TKVGGPTSVQ IWKRYVLAYP DQKETMAQSL IKMGYHGEAA
     VVLIELLNAS GDNYALWTEL VDLIGESDKL TLEPPVEQII SSGIKRFPDQ RGPLTVQLAN
     FLVRNGDLES ARDVFEDGIT TANTVRDFTV VFDAYAEFEE RIVTHLIENE SPMADLRIAK
     LDHLLERRPF LISDVRLRRE PYSVLEWQKR IALYEDPAET VAAYTEAVQS IPPAKADGKL
     SQLWISWAKF YAEDRETACE IYHKATLVPY KSVSELADVY LAWSQYESEN DHWENAVKII
     KQALESPNTH VSYHNSDLTA QDRIHKSVRL WSYYADLVES YGTFEETKQV YEKIMALDLL
     TPLFVVNYAT LLEENDHFEE MFKVYEKGIS LFEESAFEIW NLYLVKASPR LGLERLRDLF
     EDAISKFPTQ KALYILYGKL EEDRGLVRNA MRVYSAMCDH VKTSETFKYY IGRTVENFGL
     AATRPVYDKA LESLPNKDAS ELALDYAQME EKLGEIDRAR AIYGYGSQFS DPQIIKYYDA
     WHKFEVAHGT EDTFKDMLRI KRSIQAQFNT DIHYATTAAE VKKGTVQEFV KGETVQKGNI
     EPPVAQANED EIELDI