ID   SYF2_DANRE              Reviewed;         238 AA.
AC   Q6DGP2; Q5BJA7;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Pre-mRNA-splicing factor syf2;
GN   Name=syf2; ORFNames=zgc:92835;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC       spliceosome. {ECO:0000250|UniProtKB:O95926}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex.
CC       {ECO:0000250|UniProtKB:O95926}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95926}.
CC   -!- SIMILARITY: Belongs to the SYF2 family. {ECO:0000305}.
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DR   EMBL; BC076298; AAH76298.1; -; mRNA.
DR   EMBL; BC091556; AAH91556.1; -; mRNA.
DR   RefSeq; NP_001003437.1; NM_001003437.2.
DR   AlphaFoldDB; Q6DGP2; -.
DR   SMR; Q6DGP2; -.
DR   STRING; 7955.ENSDARP00000090723; -.
DR   PaxDb; Q6DGP2; -.
DR   Ensembl; ENSDART00000099950; ENSDARP00000090723; ENSDARG00000004706.
DR   GeneID; 445043; -.
DR   KEGG; dre:445043; -.
DR   CTD; 25949; -.
DR   ZFIN; ZDB-GENE-040801-170; syf2.
DR   eggNOG; KOG2609; Eukaryota.
DR   GeneTree; ENSGT00390000017845; -.
DR   HOGENOM; CLU_051065_3_0_1; -.
DR   InParanoid; Q6DGP2; -.
DR   OMA; AYSHDHK; -.
DR   OrthoDB; 1565402at2759; -.
DR   PhylomeDB; Q6DGP2; -.
DR   TreeFam; TF313041; -.
DR   Reactome; R-DRE-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q6DGP2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000004706; Expressed in testis and 30 other tissues.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR013260; mRNA_splic_SYF2.
DR   PANTHER; PTHR13264; PTHR13264; 1.
DR   Pfam; PF08231; SYF2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..238
FT                   /note="Pre-mRNA-splicing factor syf2"
FT                   /id="PRO_0000250379"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          64..85
FT                   /evidence="ECO:0000255"
FT   CONFLICT        108
FT                   /note="R -> G (in Ref. 1; AAH91556)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        148
FT                   /note="K -> R (in Ref. 1; AAH91556)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        150
FT                   /note="E -> D (in Ref. 1; AAH91556)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   238 AA;  28309 MW;  620F2EC575361CBA CRC64;
     MASSEEVVAP SNEEEVTETP AAQKREERLR KFRELHFKRN EARKLNHQEV VEEDKRLKLP
     SNWEAKKARL EYELLVDQKK KECAERGEDY DRVKLLEISA EDAERWERKK KKRNPDPGFS
     GYAEAQLRQY QRLTKQIKPD MENYEKQKEE CGEDFHPTSN SLIYGTHVPS KDSINRMVDD
     VEKQIEKRAK YSRRRAYNDD ADIDYINERN AKFNKKAERF YGKYTAEIKQ NLERGTAV