ID   SYF2_DROPS              Reviewed;         226 AA.
AC   Q28XK6;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Pre-mRNA-splicing factor Syf2;
GN   Name=Syf2; ORFNames=GA11568;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC       spliceosome. {ECO:0000250|UniProtKB:O95926}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex.
CC       {ECO:0000250|UniProtKB:O95926}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95926}.
CC   -!- SIMILARITY: Belongs to the SYF2 family. {ECO:0000305}.
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DR   EMBL; CM000071; EAL26310.1; -; Genomic_DNA.
DR   RefSeq; XP_001361731.1; XM_001361694.4.
DR   AlphaFoldDB; Q28XK6; -.
DR   SMR; Q28XK6; -.
DR   STRING; 7237.FBpp0278529; -.
DR   PRIDE; Q28XK6; -.
DR   EnsemblMetazoa; FBtr0280091; FBpp0278529; FBgn0071619.
DR   GeneID; 4805311; -.
DR   KEGG; dpo:Dpse_GA11568; -.
DR   eggNOG; KOG2609; Eukaryota.
DR   HOGENOM; CLU_051065_3_0_1; -.
DR   InParanoid; Q28XK6; -.
DR   OMA; RRRMHND; -.
DR   PhylomeDB; Q28XK6; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0071619; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; ISS:UniProtKB.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; ISS:UniProtKB.
DR   GO; GO:0071004; C:U2-type prespliceosome; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR013260; mRNA_splic_SYF2.
DR   PANTHER; PTHR13264; PTHR13264; 1.
DR   Pfam; PF08231; SYF2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..226
FT                   /note="Pre-mRNA-splicing factor Syf2"
FT                   /id="PRO_0000250385"
FT   REGION          22..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          9..29
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  26422 MW;  2F4879708BB87B08 CRC64;
     MEQSKSASDK LAERKARLLD LHKKRQEART DNHQEVVAED ARKKLPKNWE ARKRQAEWLL
     ADDKAREDAQ AAGKDYERLK LLEVSAIDAE RIEKKKKRKD NPDLGFSTYE AQTARQYSRL
     VKGMPARDME KYEKQKAELG EAFYGGPHTT LHALTKDTPA AINKMVNDLD QQIERRKKYS
     RRRIYNDDAD VDFINERNSK FNKKLDRFYG EHTAEIKQNL ERGTAI