ID   SYF2_NEUCR              Reviewed;         339 AA.
AC   Q7RZK5;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Pre-mRNA-splicing factor syf2;
DE   AltName: Full=mRNA-splicing protein 4;
GN   Name=msp-4; Synonyms=syf2; ORFNames=NCU00361;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SYF2 family. {ECO:0000305}.
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DR   EMBL; CM002238; EAA28596.1; -; Genomic_DNA.
DR   RefSeq; XP_957832.1; XM_952739.2.
DR   AlphaFoldDB; Q7RZK5; -.
DR   SMR; Q7RZK5; -.
DR   STRING; 5141.EFNCRP00000000427; -.
DR   PRIDE; Q7RZK5; -.
DR   EnsemblFungi; EAA28596; EAA28596; NCU00361.
DR   GeneID; 3873859; -.
DR   KEGG; ncr:NCU00361; -.
DR   VEuPathDB; FungiDB:NCU00361; -.
DR   HOGENOM; CLU_051065_0_1_1; -.
DR   InParanoid; Q7RZK5; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR013260; mRNA_splic_SYF2.
DR   PANTHER; PTHR13264; PTHR13264; 1.
DR   Pfam; PF08231; SYF2; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..339
FT                   /note="Pre-mRNA-splicing factor syf2"
FT                   /id="PRO_0000072378"
FT   REGION          1..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   339 AA;  37962 MW;  20F0845A97B057E7 CRC64;
     MPPEKKRKTE PEDKAEVTQQ ENDVAESTTE PNNQTVTDSK EEPSVTEAAL ATTSSSSPPV
     LSASETAQPD TAATSQSSST PPTSTSAAES AAAKARERAE RFRALQARAK SSSQQNLKKA
     TKESQRLQSD PSQLTALGRR HAIASHKLLK ADIEDAGGDF ERKRAWDWTV EESERWDKRM
     KKKEAHRDDT AFRDYNQQAE KSYKRQLRNM GGPDLERYTR EKLAAIEKAA AAGTLEIVET
     EDGEMIAIDK DGTFFSTADS TQFAQHKPDK AAVDRLVADM RKAEEASLKK RRERMANNGD
     DADVTYINEK NKQFNQKLSR FYNKYTAEIR DSFERGTMV