ID   SYF2_RAT                Reviewed;         242 AA.
AC   Q4QRB2; Q91Y33;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Pre-mRNA-splicing factor SYF2;
GN   Name=Syf2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=PVG; TISSUE=Hair follicle;
RX   PubMed=12473062; DOI=10.1034/j.1600-0625.2002.110607.x;
RA   Whitehouse C.J., Huckle J.W., Demarchez M., Reynolds A.J., Jahoda C.A.B.;
RT   "Genes that are differentially expressed in rat vibrissa follicle
RT   germinative epithelium in vivo show altered expression patterns after
RT   extended organ culture.";
RL   Exp. Dermatol. 11:542-555(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC       spliceosome. {ECO:0000250|UniProtKB:O95926}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Interacts with
CC       CCNDBP1. {ECO:0000250|UniProtKB:O95926}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95926}.
CC   -!- SIMILARITY: Belongs to the SYF2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF366369; AAK53393.1; -; mRNA.
DR   EMBL; BC097289; AAH97289.1; -; mRNA.
DR   RefSeq; NP_596908.1; NM_133417.1.
DR   AlphaFoldDB; Q4QRB2; -.
DR   IntAct; Q4QRB2; 1.
DR   STRING; 10116.ENSRNOP00000024271; -.
DR   iPTMnet; Q4QRB2; -.
DR   PhosphoSitePlus; Q4QRB2; -.
DR   PaxDb; Q4QRB2; -.
DR   PRIDE; Q4QRB2; -.
DR   Ensembl; ENSRNOT00000091494; ENSRNOP00000072888; ENSRNOG00000060597.
DR   GeneID; 170933; -.
DR   KEGG; rno:170933; -.
DR   UCSC; RGD:621592; rat.
DR   CTD; 25949; -.
DR   RGD; 621592; Syf2.
DR   eggNOG; KOG2609; Eukaryota.
DR   GeneTree; ENSGT00390000017845; -.
DR   HOGENOM; CLU_051065_3_0_1; -.
DR   InParanoid; Q4QRB2; -.
DR   OMA; RRRMHND; -.
DR   OrthoDB; 1565402at2759; -.
DR   PhylomeDB; Q4QRB2; -.
DR   TreeFam; TF313041; -.
DR   Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q4QRB2; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000060597; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q4QRB2; RN.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; ISO:RGD.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR   GO; GO:0048568; P:embryonic organ development; ISO:RGD.
DR   GO; GO:0007369; P:gastrulation; ISO:RGD.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; ISO:RGD.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
DR   InterPro; IPR013260; mRNA_splic_SYF2.
DR   PANTHER; PTHR13264; PTHR13264; 1.
DR   Pfam; PF08231; SYF2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Isopeptide bond; mRNA processing; mRNA splicing;
KW   Nucleus; Reference proteome; Spliceosome; Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O95926"
FT   CHAIN           2..242
FT                   /note="Pre-mRNA-splicing factor SYF2"
FT                   /id="PRO_0000250378"
FT   COILED          65..91
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O95926"
FT   CROSSLNK        142
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:O95926"
FT   CROSSLNK        233
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:O95926"
FT   CONFLICT        11
FT                   /note="A -> S (in Ref. 1; AAK53393)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        174
FT                   /note="S -> F (in Ref. 1; AAK53393)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   242 AA;  28712 MW;  FFCC25142541B847 CRC64;
     MAAVTEVVVP ADGAEARPLA AEELAAQKRE QRLRKFRELH LKRNEARKLN HQEVVEEDKR
     LKLPANWEAK KARLEWELQE EEKKKECAAR GEDYEKVKLL EISAEDAERW ERRKKKKNPD
     LGFSDYAAAQ LRQYHRLTKQ IKPDMESYER QREKHGEDFF PTSNSLLHGT HVPSSEEIDR
     MVLDLEKQIE KRDKYSRRRP YNDDADIDYI NERNAKFNKK AERFYGKYTA EIKQNLERGT
     AV