ID   BIR2_CAEEL              Reviewed;         308 AA.
AC   G5ECJ5;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Baculoviral IAP repeat-containing protein bir-2 {ECO:0000305};
GN   Name=bir-2 {ECO:0000312|WormBase:C50B8.2};
GN   ORFNames=C50B8.2 {ECO:0000312|WormBase:C50B8.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|EMBL:AAD00182.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Uren A.G.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3] {ECO:0000305}
RP   DEVELOPMENTAL STAGE.
RX   PubMed=10209096; DOI=10.1016/s0960-9822(99)80137-7;
RA   Fraser A.G., James C., Evan G.I., Hengartner M.O.;
RT   "Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-
RT   1 plays a conserved role in cytokinesis.";
RL   Curr. Biol. 9:292-301(1999).
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryos and in adult animals.
CC       {ECO:0000269|PubMed:10209096}.
CC   -!- SIMILARITY: Belongs to the IAP family. {ECO:0000305}.
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DR   EMBL; U72208; AAD00182.1; -; mRNA.
DR   EMBL; BX284605; CAB01130.1; -; Genomic_DNA.
DR   PIR; T37474; T37474.
DR   RefSeq; NP_506362.1; NM_073961.4.
DR   AlphaFoldDB; G5ECJ5; -.
DR   SMR; G5ECJ5; -.
DR   STRING; 6239.C50B8.2; -.
DR   EPD; G5ECJ5; -.
DR   PaxDb; G5ECJ5; -.
DR   PeptideAtlas; G5ECJ5; -.
DR   EnsemblMetazoa; C50B8.2.1; C50B8.2.1; WBGene00000250.
DR   GeneID; 179841; -.
DR   KEGG; cel:CELE_C50B8.2; -.
DR   CTD; 179841; -.
DR   WormBase; C50B8.2; CE08882; WBGene00000250; bir-2.
DR   eggNOG; KOG1101; Eukaryota.
DR   GeneTree; ENSGT00940000169803; -.
DR   HOGENOM; CLU_850571_0_0_1; -.
DR   InParanoid; G5ECJ5; -.
DR   OMA; KAGWCSA; -.
DR   OrthoDB; 1404665at2759; -.
DR   PhylomeDB; G5ECJ5; -.
DR   PRO; PR:G5ECJ5; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00000250; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00022; BIR; 2.
DR   InterPro; IPR001370; BIR_rpt.
DR   Pfam; PF00653; BIR; 2.
DR   SMART; SM00238; BIR; 2.
DR   PROSITE; PS50143; BIR_REPEAT_2; 2.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; Zinc.
FT   CHAIN           1..308
FT                   /note="Baculoviral IAP repeat-containing protein bir-2"
FT                   /id="PRO_0000441161"
FT   REPEAT          27..98
FT                   /note="BIR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   REPEAT          170..241
FT                   /note="BIR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         68
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         87
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         94
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         211
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         214
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         230
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         237
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ   SEQUENCE   308 AA;  35437 MW;  35707F95E0825AAA CRC64;
     MPYTFENSEA LLKNLKDAAP YISAAERFAS FKGFVYDKRI NIACTSEKLA RAGFYSTASP
     EFPASAKCPF CMLEINFEQC DDPWEKHKSG SPHCEFVMIG EIEESELSFR IISNLAIRHA
     TVRLYEELLG IVATLENGDI ANENPITRAD ATRKLISFRS SSKLLTFDHR LATFQNFIFD
     KKRNVKCTSK KLAKAGWFSI ANKKDKTSAK CPFCLVELDF DESDDPWEEH QKFSASCDFI
     KLGKLDEKKW TENEALMLGA RITIMQKYEK GSWLIDELEK ENRIDEIIKI RKIMIKPNHV
     LKRRRCSI