BIR51_XENTR
ID BIR51_XENTR Reviewed; 160 AA.
AC Q28H51;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Baculoviral IAP repeat-containing protein 5.1;
DE AltName: Full=Survivin1 {ECO:0000250|UniProtKB:Q8JGN5};
GN Name=birc5.1; ORFNames=TEgg052f17.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ81488.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg {ECO:0000312|EMBL:CAJ81488.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
CC complex that acts as a key regulator of mitosis. The CPC complex has
CC essential functions at the centromere in ensuring correct chromosome
CC alignment and segregation and is required for chromatin-induced
CC microtubule stabilization and spindle assembly. Stimulates the mitotic
CC kinase activity of aurkb/aurora-B in the CPC. Does not appear to
CC exhibit anti-apoptotic activity (By similarity).
CC {ECO:0000250|UniProtKB:Q8JGN5}.
CC -!- SUBUNIT: Component of the CPC at least composed of survivin/birc5,
CC incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B.
CC Interacts directly with incenp (via N-terminus), and may weakly
CC interact with aurkb (via N-terminus) to stabilize the complex.
CC Interacts with GTP-bound ran in both the S and M phases of the cell
CC cycle. Also found in a complex with ubiquitin-mediated signaling
CC proteins including at least usp9x/xFAM, nploc4/npl4 and ufd1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O15392}. Nucleus
CC {ECO:0000250|UniProtKB:O15392}. Chromosome, centromere
CC {ECO:0000250|UniProtKB:O15392}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250}. Note=Localizes on chromosome arms and inner centromeres
CC from prophase through metaphase and then transferring to the spindle
CC midzone and midbody from anaphase through cytokinesis.
CC {ECO:0000250|UniProtKB:O15392}.
CC -!- DOMAIN: C-terminus is required for spindle assembly.
CC {ECO:0000250|UniProtKB:Q8JGN5}.
CC -!- PTM: Ubiquitination is required for centrosome-targeting.
CC {ECO:0000250|UniProtKB:O15392}.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000255}.
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DR EMBL; CR761050; CAJ81488.1; -; mRNA.
DR RefSeq; NP_001037919.1; NM_001044454.1.
DR AlphaFoldDB; Q28H51; -.
DR SMR; Q28H51; -.
DR STRING; 8364.ENSXETP00000009347; -.
DR MEROPS; I32.005; -.
DR PaxDb; Q28H51; -.
DR GeneID; 733532; -.
DR KEGG; xtr:733532; -.
DR CTD; 332; -.
DR Xenbase; XB-GENE-5850943; birc5.
DR eggNOG; KOG1101; Eukaryota.
DR HOGENOM; CLU_016347_0_3_1; -.
DR InParanoid; Q28H51; -.
DR OrthoDB; 1404665at2759; -.
DR PhylomeDB; Q28H51; -.
DR TreeFam; TF105356; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000004294; Expressed in 4-cell stage embryo and 6 other tissues.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0032133; C:chromosome passenger complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR CDD; cd00022; BIR; 1.
DR InterPro; IPR001370; BIR_rpt.
DR Pfam; PF00653; BIR; 1.
DR SMART; SM00238; BIR; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Cytoplasm; Cytoskeleton; Metal-binding; Mitosis; Nucleus; Phosphoprotein;
KW Reference proteome; Ubl conjugation; Zinc.
FT CHAIN 1..160
FT /note="Baculoviral IAP repeat-containing protein 5.1"
FT /id="PRO_0000382463"
FT REPEAT 27..97
FT /note="BIR"
FT /evidence="ECO:0000255"
FT BINDING 66
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O15392,
FT ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 69
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O15392,
FT ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 86
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O15392,
FT ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O15392,
FT ECO:0000255|PROSITE-ProRule:PRU00029"
FT MOD_RES 43
FT /note="Phosphothreonine; by CDK1"
FT /evidence="ECO:0000250"
SQ SEQUENCE 160 AA; 18756 MW; D244D332EA2ACFA8 CRC64;
MHSAKNRFVQ AVQRLQDFRN MYDYEARLAT FADWPFTENC KCTPENMAKA GFVHCPTENE
PDVACCFFCL KELEGWEPDD DPWTEHSKRS ASCGFLSLTK CVNDLTMEGF LRLEADRIKS
FYRKFSTVVL QYVEEEMTAT TKRLLEYFSN QHQCSIDLDR
