ID   BIRC8_PANTR             Reviewed;         236 AA.
AC   Q95M72;
DT   11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Baculoviral IAP repeat-containing protein 8;
DE   AltName: Full=Inhibitor of apoptosis-like protein 2;
DE            Short=IAP-like protein 2;
DE            Short=ILP-2;
GN   Name=BIRC8; Synonyms=ILP2;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11390657; DOI=10.1128/mcb.21.13.4292-4301.2001;
RA   Richter B.W.M., Mir S.S., Eiben L.J., Lewis J., Reffey S.B., Frattini A.,
RA   Tian L., Frank S., Youle R.J., Nelson D.L., Notarangelo L.D., Vezzoni P.,
RA   Fearnhead H.O., Duckett C.S.;
RT   "Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis
RT   protein family.";
RL   Mol. Cell. Biol. 21:4292-4301(2001).
CC   -!- FUNCTION: Protects against apoptosis mediated by BAX. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to caspase-9. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the IAP family. {ECO:0000305}.
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DR   EMBL; AY030052; AAK49776.1; -; mRNA.
DR   RefSeq; NP_001009036.1; NM_001009036.1.
DR   AlphaFoldDB; Q95M72; -.
DR   SMR; Q95M72; -.
DR   MEROPS; I32.008; -.
DR   GeneID; 450113; -.
DR   KEGG; ptr:450113; -.
DR   CTD; 112401; -.
DR   InParanoid; Q95M72; -.
DR   OrthoDB; 1340284at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR   GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0032268; P:regulation of cellular protein metabolic process; IEA:UniProt.
DR   CDD; cd00022; BIR; 1.
DR   CDD; cd14395; UBA_BIRC4_8; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR042579; XIAP/BIRC8_UBA.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00653; BIR; 1.
DR   SMART; SM00238; BIR; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS01282; BIR_REPEAT_1; 1.
DR   PROSITE; PS50143; BIR_REPEAT_2; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..236
FT                   /note="Baculoviral IAP repeat-containing protein 8"
FT                   /id="PRO_0000122365"
FT   REPEAT          7..70
FT                   /note="BIR"
FT   ZN_FING         189..224
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   BINDING         39
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         42
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         59
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         66
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ   SEQUENCE   236 AA;  27136 MW;  64CCA3A251420EDE CRC64;
     MTGYEARLIT FGTWMYFVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK PKEDPWEQHA
     KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS LTKRINDTIF PNPMLQEAIR
     MGFDFKDVKK IMEERIQTSG SNYKTLEVLV ADLVSAQKDT TENESNQTSL QREISPEEPL
     RRLQDEKLCK ICMDRHIAVV FIPCGHLVTC KQCAEAVDRC PMCSAVIDFK QRVFMS