BIR_CHICK
ID BIR_CHICK Reviewed; 611 AA.
AC Q90660; O57319;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Inhibitor of apoptosis protein;
DE Short=IAP;
DE AltName: Full=Inhibitor of T-cell apoptosis protein;
GN Name=ITA; Synonyms=IAP1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RX PubMed=8945639; DOI=10.1089/dna.1996.15.981;
RA Digby M.R., Kimpton W.G., York J.J., Connick T.E., Lowenthal J.W.;
RT "ITA, a vertebrate homologue of IAP that is expressed in T lymphocytes.";
RL DNA Cell Biol. 15:981-988(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Embryonic fibroblast;
RX PubMed=9372964; DOI=10.1128/mcb.17.12.7328;
RA You M., Ku P.-T., Hrdlickova R., Bose H.R. Jr.;
RT "ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a
RT mediator of the antiapoptotic activity of the v-Rel oncoprotein.";
RL Mol. Cell. Biol. 17:7328-7341(1997).
CC -!- FUNCTION: Apoptotic suppressor.
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear.
CC According to PubMed:9372964 it is cytoplasmic.
CC -!- TISSUE SPECIFICITY: Cells of the T-lymphocyte lineage. Found in both
CC cortical and medullary cells of the thymus. Expressed at relatively
CC high levels also in spleen, bursa, intestine and lung and at very low
CC levels in testis, brain and skeletal muscle.
CC -!- INDUCTION: High levels are induced within 4-8 hours of T-cell
CC activation in spleen and thymus.
CC -!- DOMAIN: The ring finger is important for its antiapoptotic effect.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000305}.
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DR EMBL; U27466; AAB48118.1; -; mRNA.
DR EMBL; AF008592; AAB88044.1; -; mRNA.
DR RefSeq; NP_001007823.1; NM_001007822.1.
DR AlphaFoldDB; Q90660; -.
DR SMR; Q90660; -.
DR STRING; 9031.ENSGALP00000035646; -.
DR MEROPS; I32.002; -.
DR PaxDb; Q90660; -.
DR GeneID; 374012; -.
DR KEGG; gga:374012; -.
DR CTD; 329; -.
DR VEuPathDB; HostDB:geneid_374012; -.
DR eggNOG; KOG1101; Eukaryota.
DR HOGENOM; CLU_016347_1_1_1; -.
DR InParanoid; Q90660; -.
DR OrthoDB; 1340284at2759; -.
DR PhylomeDB; Q90660; -.
DR TreeFam; TF105356; -.
DR PRO; PR:Q90660; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:AgBase.
DR GO; GO:0060546; P:negative regulation of necroptotic process; IBA:GO_Central.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR CDD; cd00022; BIR; 3.
DR CDD; cd14394; UBA_BIRC2_3; 1.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR041933; BIRC2/BIRC3_UBA.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR Pfam; PF00653; BIR; 3.
DR Pfam; PF00619; CARD; 1.
DR SMART; SM00238; BIR; 3.
DR SMART; SM00114; CARD; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR PROSITE; PS01282; BIR_REPEAT_1; 3.
DR PROSITE; PS50143; BIR_REPEAT_2; 3.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..611
FT /note="Inhibitor of apoptosis protein"
FT /id="PRO_0000122351"
FT REPEAT 30..97
FT /note="BIR 1"
FT REPEAT 176..242
FT /note="BIR 2"
FT REPEAT 262..329
FT /note="BIR 3"
FT DOMAIN 446..536
FT /note="CARD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00046"
FT ZN_FING 564..599
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT BINDING 299
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 302
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 319
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 326
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT CONFLICT 27
FT /note="F -> L (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="R -> Q (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="Q -> H (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="S -> F (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 190..192
FT /note="CLW -> FLS (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="V -> L (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 202..203
FT /note="DD -> YY (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 213..214
FT /note="VN -> FT (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 217..218
FT /note="VK -> GQ (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 350..355
FT /note="WNSSCT -> EQLLS (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 359
FT /note="K -> T (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 426
FT /note="E -> D (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 492
FT /note="T -> K (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 497
FT /note="S -> L (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
FT CONFLICT 524
FT /note="F -> C (in Ref. 2; AAB88044)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 611 AA; 69010 MW; 53FC9136F34EBDDD CRC64;
MNIMDSSPLL ASVMKQNAHC GELKYDFSCE LYRMSTFSTF PVNVPVSERR LARAGFYYTG
VQDKVKCFSC GLVLDNWQPG DNAMEKHKQV YPSCSFVQNM LSLNNLGLST HSAFSPLVAS
NLSPSLRSMT LSPSFEQVGY FSGSFSSFPR DPVTTRAAED LSHLRSKLQN PSMSTEEARL
RTSHAWPLMC LWPAEVAKAG LDDLGTADKV ACVNCGVKLS NWEPKDNAMS EHRRHFPNCP
FVENLMRDQP SFNVSNVTMQ THEARVKTFI NWPTRIPVQP EQLADAGFYY VGRNDDVKCF
CCDGGLRCWE SGDDPWIEHA KWFPRCEYLL RVKGGEFVSQ VQARFPHLLW NSSCTTSDKP
VDENMDPIIH FEPGESPSED AIMMNTPVVK AALEMGFSRR LIKQTVQSKI LATEENYKTV
NDLVSELLTA EDEKREEEKE RQFEEVASDD LSLIRKNRMA LFQRLTSVLP ILGSLLSAKV
ITELEHDVIK QTTQTPSQAR ELIDTVLVKG NAAASIFRNC LKDFDPVLYK DLFVEKSMKY
VPTEDVSGLP MEEQLRRLQE ERTCKVCMDK EVSIVFIPCG HLVVCKECAP SLRKCPICRG
TIKGTVRTFL S
