BIVM_HUMAN
ID BIVM_HUMAN Reviewed; 503 AA.
AC Q86UB2; Q2M1J2; Q9NXM4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Basic immunoglobulin-like variable motif-containing protein;
GN Name=BIVM;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 71-503 (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-503 (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=12036287; DOI=10.1006/geno.2002.6768;
RA Yoder J.A., Hawke N.A., Eason D.D., Mueller M.G., Davids B.J., Gillin F.D.,
RA Litman G.W.;
RT "BIVM, a novel gene widely distributed among deuterostomes, shares a core
RT sequence with an unusual gene in Giardia lamblia.";
RL Genomics 79:750-755(2002).
CC -!- INTERACTION:
CC Q86UB2; A0A0A0MR97: BAZ2B; NbExp=3; IntAct=EBI-12191873, EBI-11985607;
CC Q86UB2; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-12191873, EBI-739909;
CC Q86UB2; P25800: LMO1; NbExp=3; IntAct=EBI-12191873, EBI-8639312;
CC Q86UB2; Q8IXY8: PPIL6; NbExp=3; IntAct=EBI-12191873, EBI-12226639;
CC Q86UB2; Q5MJ10: SPANXN2; NbExp=5; IntAct=EBI-12191873, EBI-12023934;
CC Q86UB2; Q13114: TRAF3; NbExp=6; IntAct=EBI-12191873, EBI-357631;
CC Q86UB2; Q12899: TRIM26; NbExp=3; IntAct=EBI-12191873, EBI-2341136;
CC Q86UB2; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-12191873, EBI-725997;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12036287}. Nucleus
CC {ECO:0000269|PubMed:12036287}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86UB2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86UB2-2; Sequence=VSP_032855, VSP_032856;
CC -!- TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in
CC spleen, ovary, small intestine, colon, peripheral blood leukocytes and
CC liver. Also expressed in testis, ovary, aorta, appendix, trachea,
CC pituitary gland, bladder, uterus, spinal cord, salivary gland, stomach,
CC mammary gland and bone marrow. Weakly or not expressed in fetal spleen,
CC adult thymus and certain cancer cell lines.
CC {ECO:0000269|PubMed:12036287}.
CC -!- SIMILARITY: Belongs to the BIVM family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH51813.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA90986.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL157769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC051813; AAH51813.2; ALT_INIT; mRNA.
DR EMBL; BC112339; AAI12340.1; -; mRNA.
DR EMBL; AK000166; BAA90986.1; ALT_INIT; mRNA.
DR CCDS; CCDS53879.1; -. [Q86UB2-2]
DR CCDS; CCDS9505.1; -. [Q86UB2-1]
DR RefSeq; NP_001153068.1; NM_001159596.1. [Q86UB2-2]
DR RefSeq; NP_060163.2; NM_017693.3. [Q86UB2-1]
DR AlphaFoldDB; Q86UB2; -.
DR BioGRID; 120192; 11.
DR IntAct; Q86UB2; 8.
DR STRING; 9606.ENSP00000257336; -.
DR iPTMnet; Q86UB2; -.
DR PhosphoSitePlus; Q86UB2; -.
DR BioMuta; BIVM; -.
DR DMDM; 182627634; -.
DR jPOST; Q86UB2; -.
DR MassIVE; Q86UB2; -.
DR MaxQB; Q86UB2; -.
DR PaxDb; Q86UB2; -.
DR PeptideAtlas; Q86UB2; -.
DR PRIDE; Q86UB2; -.
DR Antibodypedia; 11219; 111 antibodies from 24 providers.
DR DNASU; 54841; -.
DR Ensembl; ENST00000257336.6; ENSP00000257336.1; ENSG00000134897.14. [Q86UB2-1]
DR Ensembl; ENST00000448849.3; ENSP00000412794.2; ENSG00000134897.14. [Q86UB2-2]
DR Ensembl; ENST00000652084.1; ENSP00000498544.1; ENSG00000134897.14. [Q86UB2-1]
DR GeneID; 54841; -.
DR KEGG; hsa:54841; -.
DR MANE-Select; ENST00000257336.6; ENSP00000257336.1; NM_017693.4; NP_060163.2.
DR UCSC; uc001vps.4; human. [Q86UB2-1]
DR CTD; 54841; -.
DR DisGeNET; 54841; -.
DR GeneCards; BIVM; -.
DR HGNC; HGNC:16034; BIVM.
DR HPA; ENSG00000134897; Low tissue specificity.
DR MIM; 619006; gene.
DR neXtProt; NX_Q86UB2; -.
DR OpenTargets; ENSG00000134897; -.
DR PharmGKB; PA25366; -.
DR VEuPathDB; HostDB:ENSG00000134897; -.
DR eggNOG; ENOG502QUM8; Eukaryota.
DR GeneTree; ENSGT00510000048601; -.
DR HOGENOM; CLU_041921_1_0_1; -.
DR InParanoid; Q86UB2; -.
DR OMA; CDFRGRV; -.
DR OrthoDB; 1429720at2759; -.
DR PhylomeDB; Q86UB2; -.
DR TreeFam; TF331304; -.
DR PathwayCommons; Q86UB2; -.
DR SignaLink; Q86UB2; -.
DR BioGRID-ORCS; 54841; 19 hits in 1069 CRISPR screens.
DR ChiTaRS; BIVM; human.
DR GenomeRNAi; 54841; -.
DR Pharos; Q86UB2; Tdark.
DR PRO; PR:Q86UB2; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q86UB2; protein.
DR Bgee; ENSG00000134897; Expressed in left ventricle myocardium and 174 other tissues.
DR ExpressionAtlas; Q86UB2; baseline and differential.
DR Genevisible; Q86UB2; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR038819; BIVM.
DR PANTHER; PTHR16171:SF9; PTHR16171:SF9; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..503
FT /note="Basic immunoglobulin-like variable motif-containing
FT protein"
FT /id="PRO_0000328955"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..229
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032855"
FT VAR_SEQ 406
FT /note="K -> KPTFFSSQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032856"
FT CONFLICT 224
FT /note="N -> D (in Ref. 3; BAA90986)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 503 AA; 56774 MW; DC383629599388CF CRC64;
MPNVAETERS NDSGNGEHKS ERKSPEENLQ GAVKSFCTSA SGAPLGPKGD GHYPWSCPVT
HTREKIYAIC SDYAFLNQAT SIYKTPNPSR SPCLPDSTSL SAGNNSSRYI GIPTSTSEII
YNEENSLENL SNSLGKLPLA WEIDKSEFDG VTTNSKHKSG NAKKQVSKRK TSDKKGRYQK
ECPQHSPLED IKQRKVLDLR RWYCISRPQY KTSCGISSLI SCWNFLYSTM GAGNLPPITQ
EEALHILGFQ PPFEDIRFGP FTGNTTLMRW FRQINDHFHV KGCSYVLYKP HGKNKTAGET
ASGALSKLTR GLKDESLAYI YHCQNHYFCP IGFEATPVKA NKAFSRGPLS PQEVEYWILI
GESSRKHPAI HCKKWADIVT DLNTQNPEYL DIRHLERGLQ YRKTKKVGGN LHCIIAFQRL
NWQRFGLWNF PFGTIRQESQ PPTHAQGIAK SESEDNISKK QHGRLGRSFS ASFHQDSAWK
KMSSIHERRN SGYQGYSDYD GND
