ID   BKIP_CROVV              Reviewed;          11 AA.
AC   P85024;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Bradykinin inhibitor peptide;
DE            Short=BIP;
OS   Crotalus viridis viridis (Prairie rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=8742;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000269|PubMed:16277978};
RX   PubMed=16277978; DOI=10.1016/j.bbrc.2005.10.130;
RA   Graham R.L.J., Graham C., McClean S., Chen T., O'Rourke M., Hirst D.,
RA   Theakston D., Shaw C.;
RT   "Identification and functional analysis of a novel bradykinin inhibitory
RT   peptide in the venoms of new world crotalinae pit vipers.";
RL   Biochem. Biophys. Res. Commun. 338:1587-1592(2005).
CC   -!- FUNCTION: Bradykinin inhibitor peptide antagonizes the vasodilatory
CC       actions of bradykinin at the B2 bradykinin receptor (BDKRB2).
CC       {ECO:0000269|PubMed:16277978}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16277978}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=1063.18; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16277978};
CC   -!- SIMILARITY: Belongs to the bradykinin inhibitor peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
DR   GO; GO:0044498; P:envenomation resulting in modulation of blood pressure in another organism; IDA:UniProtKB.
DR   GO; GO:0044503; P:modulation of G protein-coupled receptor activity in another organism; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Bradykinin receptor impairing toxin; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Secreted; Toxin; Vasoactive.
FT   PEPTIDE         1..11
FT                   /note="Bradykinin inhibitor peptide"
FT                   /evidence="ECO:0000269|PubMed:16277978"
FT                   /id="PRO_0000258039"
SQ   SEQUENCE   11 AA;  1063 MW;  C4423866CAB7687D CRC64;
     TPPAGPDVGP R