BKRB1_HUMAN
ID BKRB1_HUMAN Reviewed; 353 AA.
AC P46663; A8K7F5; Q546S7; Q8N0Y8;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 3.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=B1 bradykinin receptor;
DE Short=B1R;
DE Short=BK-1 receptor;
GN Name=BDKRB1; Synonyms=BRADYB1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=8063797; DOI=10.1016/s0021-9258(17)31844-6;
RA Menke J.G., Borkowski J.A., Bierilo K.K., Macneil T., Derrick A.W.,
RA Schneck K.A., Ransom R.W., Strader C.D., Linemeyer D.L., Hess J.F.;
RT "Expression cloning of a human B1 bradykinin receptor.";
RL J. Biol. Chem. 269:21583-21586(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8651911; DOI=10.1006/bbrc.1996.0810;
RA Yang X., Polgar P.;
RT "Genomic structure of the human bradykinin B1 receptor gene and preliminary
RT characterization of its regulatory regions.";
RL Biochem. Biophys. Res. Commun. 222:718-725(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8660997; DOI=10.1006/geno.1996.0213;
RA Bachvarov D.R., Hess J.F., Menke J.G., Larrivee J.F., Marceau F.;
RT "Structure and genomic organization of the human B1 receptor gene for
RT kinins (BDKRB1).";
RL Genomics 33:374-381(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC TISSUE=Lung;
RX PubMed=10422787; DOI=10.1016/s0014-2999(99)00315-5;
RA Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M.,
RA Docherty R.J., Webb M., Bevan S.J., McIntyre P.;
RT "Molecular characterisation of cloned bradykinin B1 receptors from rat and
RT human.";
RL Eur. J. Pharmacol. 374:423-433(1999).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Warren C.N., Aronstam R.S., Sharma S.V.;
RT "Isolation of complete coding sequence for bradykinin receptor B1
RT (BDKRB1).";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in
CC chronic pain and inflammation. {ECO:0000269|PubMed:8063797,
CC ECO:0000269|PubMed:8660997}.
CC -!- INTERACTION:
CC P46663; PRO_0000006687 [P01042]: KNG1; NbExp=2; IntAct=EBI-6623218, EBI-6623250;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8063797};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Bradykinin receptor entry;
CC URL="https://en.wikipedia.org/wiki/Bradykinin_receptor";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U12512; AAA21346.1; -; mRNA.
DR EMBL; U22346; AAC50594.1; -; Genomic_DNA.
DR EMBL; U48231; AAB60693.1; -; Genomic_DNA.
DR EMBL; AJ238044; CAB45650.1; -; mRNA.
DR EMBL; AB065896; BAC06112.1; -; Genomic_DNA.
DR EMBL; AY275464; AAP32296.1; -; Genomic_DNA.
DR EMBL; AK291970; BAF84659.1; -; mRNA.
DR EMBL; CH471061; EAW81632.1; -; Genomic_DNA.
DR EMBL; BC034705; AAH34705.1; -; mRNA.
DR CCDS; CCDS9943.1; -.
DR PIR; A53858; A53858.
DR RefSeq; NP_000701.2; NM_000710.3.
DR PDB; 7EIB; EM; 3.00 A; A=2-350.
DR PDBsum; 7EIB; -.
DR AlphaFoldDB; P46663; -.
DR SMR; P46663; -.
DR BioGRID; 107092; 32.
DR IntAct; P46663; 32.
DR MINT; P46663; -.
DR STRING; 9606.ENSP00000216629; -.
DR BindingDB; P46663; -.
DR ChEMBL; CHEMBL4308; -.
DR DrugBank; DB01197; Captopril.
DR DrugBank; DB09477; Enalaprilat.
DR DrugBank; DB00178; Ramipril.
DR DrugBank; DB01593; Zinc.
DR DrugBank; DB14487; Zinc acetate.
DR DrugBank; DB14533; Zinc chloride.
DR DrugBank; DB14548; Zinc sulfate, unspecified form.
DR DrugCentral; P46663; -.
DR GuidetoPHARMACOLOGY; 41; -.
DR GlyGen; P46663; 3 sites.
DR iPTMnet; P46663; -.
DR PhosphoSitePlus; P46663; -.
DR BioMuta; BDKRB1; -.
DR DMDM; 85681914; -.
DR MassIVE; P46663; -.
DR PaxDb; P46663; -.
DR PeptideAtlas; P46663; -.
DR PRIDE; P46663; -.
DR ProteomicsDB; 55746; -.
DR Antibodypedia; 153; 322 antibodies from 36 providers.
DR DNASU; 623; -.
DR Ensembl; ENST00000216629.11; ENSP00000216629.6; ENSG00000100739.11.
DR Ensembl; ENST00000611804.1; ENSP00000479276.1; ENSG00000100739.11.
DR GeneID; 623; -.
DR KEGG; hsa:623; -.
DR MANE-Select; ENST00000216629.11; ENSP00000216629.6; NM_000710.4; NP_000701.2.
DR UCSC; uc001yfh.4; human.
DR CTD; 623; -.
DR DisGeNET; 623; -.
DR GeneCards; BDKRB1; -.
DR HGNC; HGNC:1029; BDKRB1.
DR HPA; ENSG00000100739; Tissue enhanced (gallbladder, urinary bladder).
DR MIM; 600337; gene.
DR neXtProt; NX_P46663; -.
DR OpenTargets; ENSG00000100739; -.
DR PharmGKB; PA79; -.
DR VEuPathDB; HostDB:ENSG00000100739; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234534; -.
DR InParanoid; P46663; -.
DR OMA; QGCFWEE; -.
DR OrthoDB; 951204at2759; -.
DR PhylomeDB; P46663; -.
DR TreeFam; TF330024; -.
DR PathwayCommons; P46663; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; P46663; -.
DR SIGNOR; P46663; -.
DR BioGRID-ORCS; 623; 11 hits in 1070 CRISPR screens.
DR ChiTaRS; BDKRB1; human.
DR GeneWiki; Bradykinin_receptor_B1; -.
DR GenomeRNAi; 623; -.
DR Pharos; P46663; Tchem.
DR PRO; PR:P46663; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; P46663; protein.
DR Bgee; ENSG00000100739; Expressed in gall bladder and 87 other tissues.
DR ExpressionAtlas; P46663; baseline and differential.
DR Genevisible; P46663; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004947; F:bradykinin receptor activity; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc.
DR GO; GO:0002687; P:positive regulation of leukocyte migration; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:InterPro.
DR GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR InterPro; IPR001186; Brdyknn_1_rcpt.
DR InterPro; IPR000496; Brdyknn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00425; BRADYKININR.
DR PRINTS; PR00993; BRADYKINNB1R.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..353
FT /note="B1 bradykinin receptor"
FT /id="PRO_0000069181"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..291
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..314
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 330
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 110..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 250
FT /note="A -> V (in dbSNP:rs2229459)"
FT /id="VAR_014359"
FT VARIANT 317
FT /note="R -> Q (in dbSNP:rs8004609)"
FT /id="VAR_049376"
FT CONFLICT 146
FT /note="R -> G (in Ref. 1, 2 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 240..243
FT /note="CGGR -> VRGP (in Ref. 1, 2 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 246
FT /note="S -> R (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="F -> S (in Ref. 2; AAC50594)"
FT /evidence="ECO:0000305"
FT HELIX 31..63
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 71..88
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 90..97
FT /evidence="ECO:0007829|PDB:7EIB"
FT TURN 98..101
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 107..140
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 144..147
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 150..167
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 170..175
FT /evidence="ECO:0007829|PDB:7EIB"
FT STRAND 176..180
FT /evidence="ECO:0007829|PDB:7EIB"
FT TURN 182..184
FT /evidence="ECO:0007829|PDB:7EIB"
FT STRAND 187..191
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 197..210
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 212..238
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 247..277
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 284..301
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 303..312
FT /evidence="ECO:0007829|PDB:7EIB"
FT TURN 313..315
FT /evidence="ECO:0007829|PDB:7EIB"
FT HELIX 317..324
FT /evidence="ECO:0007829|PDB:7EIB"
FT TURN 325..329
FT /evidence="ECO:0007829|PDB:7EIB"
SQ SEQUENCE 353 AA; 40495 MW; B62B0690A7593077 CRC64;
MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL
VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN
LFISIFLVVA ISQDRYRVLV HPMASRRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA
VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC
GGRKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF
AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN
