BKRB1_MACFA
ID BKRB1_MACFA Reviewed; 352 AA.
AC Q3BCU0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=B1 bradykinin receptor;
DE Short=B1R;
DE Short=BK-1 receptor;
GN Name=BDKRB1;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RA Coombs S., Cortright D., Peck A.;
RT "Cynomolgus monkey (Macaca fascicularis) bradykinin receptor B1 gene.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in
CC chronic pain and inflammation. {ECO:0000250|UniProtKB:P46663}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P46663};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY788905; AAX14712.1; -; mRNA.
DR RefSeq; NP_001271812.1; NM_001284883.1.
DR RefSeq; XP_015308746.1; XM_015453260.1.
DR AlphaFoldDB; Q3BCU0; -.
DR SMR; Q3BCU0; -.
DR BindingDB; Q3BCU0; -.
DR ChEMBL; CHEMBL5155; -.
DR GeneID; 102123453; -.
DR KEGG; mcf:102123453; -.
DR CTD; 623; -.
DR OrthoDB; 951204at2759; -.
DR PRO; PR:Q3BCU0; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004947; F:bradykinin receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:InterPro.
DR InterPro; IPR001186; Brdyknn_1_rcpt.
DR InterPro; IPR000496; Brdyknn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00425; BRADYKININR.
DR PRINTS; PR00993; BRADYKINNB1R.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..352
FT /note="B1 bradykinin receptor"
FT /id="PRO_0000069182"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..294
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..352
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 329
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 109..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 352 AA; 40217 MW; D9B2554238B94BD5 CRC64;
MASWPPLQLQ SSNQSQLFPQ NATACDNAPE AWDLLHRVLP TFIISICSFG LLGNLFVLLV
FLLPRRRLNV AEIYLANLAA SDLVFVLGLP FWAENIWNQF NWPFGALLCR VINGIIKANL
FISIFLVVAI SQDRYCVLVH PMASRRRQRR RQARVTCVLI WVVGGLLSIP TFLLRSIQAV
PDLNITACIL LLPHEAWHFA RIVELNILAF LLPLAAIIFF NYHILASLRG REEVSRTRCG
GSKDSKTTAL ILTLVVAFLV CWAPYHFFAF LEFLFQVQAV RGCFWEDFID LGLQLANFLA
FTNSSLNPVI YVFAGRLFRT KVWELYKQCT PKSLAPISSS HRKEIFQLFW RN
