BKRB1_MACMU
ID BKRB1_MACMU Reviewed; 352 AA.
AC Q8HZP2; Q95L02;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=B1 bradykinin receptor;
DE Short=B1R;
DE Short=BK-1 receptor;
GN Name=BDKRB1;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Horlick R.A., Zhao J., Swanson R.N., Webb M.L., Strohl B., Baldwin J.J.,
RA Auld D.S.;
RT "Orthologs of human receptors and methods of use.";
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hess F., Hey P.;
RT "Molecular cloning of rhesus monkey B1 bradykinin receptor.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in
CC chronic pain and inflammation. {ECO:0000250|UniProtKB:P46663}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P46663};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF540785; AAN16464.1; -; Genomic_DNA.
DR EMBL; AY045568; AAK95386.1; -; Genomic_DNA.
DR RefSeq; XP_014999945.1; XM_015144459.1.
DR AlphaFoldDB; Q8HZP2; -.
DR SMR; Q8HZP2; -.
DR BindingDB; Q8HZP2; -.
DR ChEMBL; CHEMBL1250405; -.
DR GeneID; 712251; -.
DR KEGG; mcc:712251; -.
DR CTD; 623; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q8HZP2; -.
DR OrthoDB; 951204at2759; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004947; F:bradykinin receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:InterPro.
DR InterPro; IPR001186; Brdyknn_1_rcpt.
DR InterPro; IPR000496; Brdyknn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00425; BRADYKININR.
DR PRINTS; PR00993; BRADYKINNB1R.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..352
FT /note="B1 bradykinin receptor"
FT /id="PRO_0000069183"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..294
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..352
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 329
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 109..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 8
FT /note="E -> Q (in Ref. 2; AAK95386)"
FT /evidence="ECO:0000305"
FT CONFLICT 314
FT /note="V -> A (in Ref. 2; AAK95386)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 352 AA; 40246 MW; 9254149620ED896D CRC64;
MASWPPLELQ SSNQSQLFPQ NATACDNAPE AWDLLHRVLP TFIISICSFG LLGNLFVLLV
FLLPRRRLNV AEIYLANLAA SDLVFVLGLP FWAENIWNQF NWPFGALLCR VINGIIKANL
FISIFLVVAI SQDRYCVLVH PMASRRRQRR RQARVTCVLI WVVGGLLSIP TFLLRSIQAV
PDLNITACIL LLPHEAWHFA RIVELNILAF LLPLAAIIFF NYHILASLRG REEVSRTRCG
GSKDSKTTAL ILTLVVAFLV CWAPYHFFAF LEFLFQVQAV RGCFWEDFID LGLQLANFLA
FTNSSLNPVI YVFVGRLFRT KVWELYKQCT PKSLAPISSS HRKEIFQLFW RN
