BKRB1_MOUSE
ID BKRB1_MOUSE Reviewed; 334 AA.
AC Q61125; Q9Z1F4;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=B1 bradykinin receptor;
DE Short=B1R;
DE Short=BK-1 receptor;
GN Name=Bdkrb1; Synonyms=Bdkrb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC STRAIN=129/SvJ;
RX PubMed=8602848; DOI=10.1006/bbrc.1996.0384;
RA Pesquero J.B., Pesquero J.L., Oliveira S.M., Roscher A.A., Metzger R.,
RA Ganten D., Bader M.;
RT "Molecular cloning and functional characterization of a mouse bradykinin B1
RT receptor gene.";
RL Biochem. Biophys. Res. Commun. 220:219-225(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Yanagawa T., Prado G.N., Paquet J.L., Bestian S., Cousins B., Navarro J.;
RT "Novel pharmacological selectivity of the cloned murine B1 bradykinin
RT receptor.";
RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in
CC chronic pain and inflammation. {ECO:0000250|UniProtKB:P46663}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P46663};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in heart, liver and lung.
CC -!- INDUCTION: By lipopolysaccharide (LPS) in heart, liver and lung five
CC hours after treatment. {ECO:0000269|PubMed:8602848}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U47281; AAA99778.1; -; Genomic_DNA.
DR EMBL; U44436; AAD00029.1; -; Genomic_DNA.
DR CCDS; CCDS26155.1; -.
DR PIR; JC4681; JC4681.
DR RefSeq; NP_031565.1; NM_007539.3.
DR AlphaFoldDB; Q61125; -.
DR SMR; Q61125; -.
DR STRING; 10090.ENSMUSP00000045335; -.
DR BindingDB; Q61125; -.
DR ChEMBL; CHEMBL1250407; -.
DR GuidetoPHARMACOLOGY; 41; -.
DR GlyGen; Q61125; 3 sites.
DR PhosphoSitePlus; Q61125; -.
DR PaxDb; Q61125; -.
DR PRIDE; Q61125; -.
DR Antibodypedia; 153; 322 antibodies from 36 providers.
DR DNASU; 12061; -.
DR Ensembl; ENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347.
DR Ensembl; ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347.
DR GeneID; 12061; -.
DR KEGG; mmu:12061; -.
DR UCSC; uc007oyn.1; mouse.
DR CTD; 623; -.
DR MGI; MGI:88144; Bdkrb1.
DR VEuPathDB; HostDB:ENSMUSG00000041347; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234534; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; Q61125; -.
DR OMA; QGCFWEE; -.
DR OrthoDB; 951204at2759; -.
DR PhylomeDB; Q61125; -.
DR TreeFam; TF330024; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 12061; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q61125; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q61125; protein.
DR Bgee; ENSMUSG00000041347; Expressed in choroid plexus of fourth ventricle and 26 other tissues.
DR ExpressionAtlas; Q61125; baseline and differential.
DR Genevisible; Q61125; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004947; F:bradykinin receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IDA:MGI.
DR GO; GO:0016477; P:cell migration; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; ISO:MGI.
DR GO; GO:0045776; P:negative regulation of blood pressure; ISO:MGI.
DR GO; GO:0030308; P:negative regulation of cell growth; ISO:MGI.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; ISO:MGI.
DR GO; GO:0002687; P:positive regulation of leukocyte migration; ISO:MGI.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISO:MGI.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0032496; P:response to lipopolysaccharide; IDA:MGI.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:InterPro.
DR GO; GO:0019233; P:sensory perception of pain; ISO:MGI.
DR InterPro; IPR001186; Brdyknn_1_rcpt.
DR InterPro; IPR000496; Brdyknn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00425; BRADYKININR.
DR PRINTS; PR00993; BRADYKINNB1R.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..334
FT /note="B1 bradykinin receptor"
FT /id="PRO_0000069184"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..214
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..334
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 117..196
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 216
FT /note="L -> V (in Ref. 2; AAD00029)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="L -> P (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 263..265
FT /note="VAS -> SSL (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 331..334
FT /note="LGTL -> WELYKRCTSLKNAVLPSRKELFQLSCWN (in Ref. 2;
FT AAD00029)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 334 AA; 37886 MW; 77C806203AC5C6CC CRC64;
MASQASLKLQ PSNQSQQAPP NITSCEGAPE AWDLLCRVLP GFVITVCFFG LLGNLLVLSF
FLLPWRRWWQ QRRQRLTIAE IYLANLAASD LVFVLGLPFW AENVGNRFNW PFGSDLCRVV
SGVIKANLFI SIFLVVAISQ DRYRLLVYPM TSWGNRRRRQ AQVTCLLIWV AGGLLSTPTF
LLRSVKVVPD LNISACILLF PHEAWHFVRM VELNVLGFLL PLAAILYFNF HILASLRGQK
EASRTRCGGP KDSKTMGLIL TLVASFLVCW APYHFFAFLD FLVQVRVIQD CFWKELTDLG
LQLANFFAFV NSCLNPLIYV FAGRLFKTRV LGTL
