BKRB1_RABIT
ID BKRB1_RABIT Reviewed; 352 AA.
AC P48748;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=B1 bradykinin receptor;
DE Short=B1R;
DE Short=BK-1 receptor;
GN Name=BDKRB1;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=New Zealand white; TISSUE=Aorta;
RX PubMed=7495867; DOI=10.1016/0167-4781(95)00152-7;
RA Macneil T., Bierilo K.K., Menke J.G., Hess J.F.;
RT "Cloning and pharmacological characterization of a rabbit bradykinin B1
RT receptor.";
RL Biochim. Biophys. Acta 1264:223-228(1995).
CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in
CC chronic pain and inflammation. {ECO:0000269|PubMed:7495867}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P46663};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- INDUCTION: In response to tissue injury.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U20507; AAC48482.1; -; mRNA.
DR PIR; S60024; S60024.
DR RefSeq; NP_001075816.1; NM_001082347.1.
DR AlphaFoldDB; P48748; -.
DR SMR; P48748; -.
DR STRING; 9986.ENSOCUP00000022849; -.
DR BindingDB; P48748; -.
DR ChEMBL; CHEMBL4087; -.
DR GeneID; 100009198; -.
DR KEGG; ocu:100009198; -.
DR CTD; 623; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P48748; -.
DR OrthoDB; 826485at2759; -.
DR PRO; PR:P48748; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004947; F:bradykinin receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:InterPro.
DR InterPro; IPR001186; Brdyknn_1_rcpt.
DR InterPro; IPR000496; Brdyknn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00425; BRADYKININR.
DR PRINTS; PR00993; BRADYKINNB1R.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..352
FT /note="B1 bradykinin receptor"
FT /id="PRO_0000069186"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..314
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..352
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 329
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 109..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 352 AA; 39503 MW; 492AD177258853CD CRC64;
MASQGPLELQ PSNQSQLAPP NATSCSGAPD AWDLLHRLLP TFIIAIFTLG LLGNSFVLSV
FLLARRRLSV AEIYLANLAA SDLVFVLGLP FWAENVRNQF DWPFGAALCR IVNGVIKANL
FISIFLVVAI SQDRYSVLVH PMASRRGRRR RQAQATCALI WLAGGLLSTP TFVLRSVRAV
PELNVSACIL LLPHEAWHWL RMVELNLLGF LLPLAAILFF NCHILASLRR RGERVPSRCG
GPRDSKSTAL ILTLVASFLV CWAPYHFFAF LECLWQVHAI GGCFWEEFTD LGLQLSNFSA
FVNSCLNPVI YVFVGRLFRT KVWELCQQCS PRSLAPVSSS RRKEMLWGFW RN
