位置:首页 > 蛋白库 > BKRB1_RAT
BKRB1_RAT
ID   BKRB1_RAT               Reviewed;         337 AA.
AC   P97583; O35782; Q9R250;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 2.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=B1 bradykinin receptor;
DE            Short=B1R;
DE            Short=BK-1 receptor;
DE   AltName: Full=Kinin B1 receptor;
DE            Short=KB1;
GN   Name=Bdkrb1; Synonyms=B1bkr, Bkr;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=9804950; DOI=10.1016/s0167-4781(98)00163-8;
RA   Ni A., Chai K.X., Chao L., Chao J.;
RT   "Molecular cloning and expression of rat bradykinin B1 receptor.";
RL   Biochim. Biophys. Acta 1442:177-185(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC   STRAIN=Sprague-Dawley; TISSUE=Urinary bladder;
RX   PubMed=10422787; DOI=10.1016/s0014-2999(99)00315-5;
RA   Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M.,
RA   Docherty R.J., Webb M., Bevan S.J., McIntyre P.;
RT   "Molecular characterisation of cloned bradykinin B1 receptors from rat and
RT   human.";
RL   Eur. J. Pharmacol. 374:423-433(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley;
RA   Oliveira S.M., Araujo R.C., Pesquero J.L., Bader M., Pesquero J.B.;
RT   "Molecular cloning of a rat kinin B1 receptor gene.";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 1-15.
RC   STRAIN=Sprague-Dawley;
RA   Schanstra J.P., Girolami J.P., Bascands J.L.;
RT   "Rat bradykinin B1 gene, promoter region, exon 1, intron 1, and exon 2.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in
CC       chronic pain and inflammation. {ECO:0000250|UniProtKB:P46663}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P46663};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in bladder, lung, duodenum, kidney,
CC       uterus, thymus, salivary gland, testis, prostate, macrophages, aorta,
CC       spleen and heart.
CC   -!- INDUCTION: By lipopolysaccharide (LPS), four hours after treatment
CC       levels show an increase in many tissues. After 12 hours maximum levels
CC       are observed in the heart. {ECO:0000269|PubMed:10422787,
CC       ECO:0000269|PubMed:9804950}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U66107; AAC78505.2; -; mRNA.
DR   EMBL; AJ132230; CAA10610.1; -; mRNA.
DR   EMBL; AF009899; AAB63592.1; -; Genomic_DNA.
DR   EMBL; AF114406; AAD29286.1; -; Genomic_DNA.
DR   RefSeq; NP_110478.1; NM_030851.1.
DR   RefSeq; XP_008763083.1; XM_008764861.2.
DR   AlphaFoldDB; P97583; -.
DR   SMR; P97583; -.
DR   STRING; 10116.ENSRNOP00000005953; -.
DR   BindingDB; P97583; -.
DR   ChEMBL; CHEMBL4613; -.
DR   DrugCentral; P97583; -.
DR   GuidetoPHARMACOLOGY; 41; -.
DR   GlyGen; P97583; 3 sites.
DR   PhosphoSitePlus; P97583; -.
DR   PaxDb; P97583; -.
DR   Ensembl; ENSRNOT00000005953; ENSRNOP00000005953; ENSRNOG00000004488.
DR   GeneID; 81509; -.
DR   KEGG; rno:81509; -.
DR   UCSC; RGD:620401; rat.
DR   CTD; 623; -.
DR   RGD; 620401; Bdkrb1.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01030000234534; -.
DR   HOGENOM; CLU_009579_8_3_1; -.
DR   InParanoid; P97583; -.
DR   OMA; QGCFWEE; -.
DR   OrthoDB; 951204at2759; -.
DR   PhylomeDB; P97583; -.
DR   TreeFam; TF330024; -.
DR   Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR   Reactome; R-RNO-416476; G alpha (q) signalling events.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:P97583; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000004488; Expressed in stomach and 4 other tissues.
DR   Genevisible; P97583; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IDA:RGD.
DR   GO; GO:0043005; C:neuron projection; IDA:RGD.
DR   GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR   GO; GO:0004947; F:bradykinin receptor activity; IDA:RGD.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0042277; F:peptide binding; IPI:RGD.
DR   GO; GO:0016477; P:cell migration; IMP:RGD.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IMP:RGD.
DR   GO; GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
DR   GO; GO:0030308; P:negative regulation of cell growth; IMP:RGD.
DR   GO; GO:0001933; P:negative regulation of protein phosphorylation; IMP:RGD.
DR   GO; GO:0002687; P:positive regulation of leukocyte migration; IMP:RGD.
DR   GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:RGD.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IDA:RGD.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0009612; P:response to mechanical stimulus; IEA:InterPro.
DR   GO; GO:0019233; P:sensory perception of pain; IMP:RGD.
DR   InterPro; IPR001186; Brdyknn_1_rcpt.
DR   InterPro; IPR000496; Brdyknn_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00425; BRADYKININR.
DR   PRINTS; PR00993; BRADYKINNB1R.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..337
FT                   /note="B1 bradykinin receptor"
FT                   /id="PRO_0000069187"
FT   TOPO_DOM        1..41
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..121
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        143..164
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..217
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        239..261
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        283..305
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        327..337
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        21
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        120..199
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   337 AA;  38378 MW;  226828DF0F26BA8E CRC64;
     MASEVLLELQ PSNRSLQAPA NITSCESALE DWDLLYRVLP GFVITICFFG LLGNLLVLSF
     FLLPWRQWWW QQRQRQQRLT IAEIYLANLA ASDLVFVLGL PFWAENIGNR FNWPFGTDLC
     RVVSGVIKAN LFVSIFLVVA ISQDRYRLLV YPMTSWGYRR RRQAQATCLL IWVAGGLLSI
     PTFLLRSVKV VPDLNVSACI LLFPHEAWHF ARMVELNVLG FLLPVTAIIF FNYHILASLR
     GQKEASRTRC GGPKGSKTTG LILTLVASFL VCWCPYHFFA FLDFLVQVRV IQDCSWKEIT
     DLGLQLANFF AFVNSCLNPL IYVFAGRLLK TRVLGTL
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024