ID   SYG1_SCHPO              Reviewed;         682 AA.
AC   Q9UU86; O74979;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Protein SYG1 homolog;
GN   ORFNames=SPCC1827.07c, SPCP1E11.01c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: May function in G-protein coupled signal transduction.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA19315.1; -; Genomic_DNA.
DR   PIR; T41168; T41168.
DR   PIR; T41680; T41680.
DR   RefSeq; NP_588554.2; NM_001023540.3.
DR   AlphaFoldDB; Q9UU86; -.
DR   BioGRID; 280230; 1.
DR   STRING; 4896.SPCC1827.07c.1; -.
DR   iPTMnet; Q9UU86; -.
DR   MaxQB; Q9UU86; -.
DR   PaxDb; Q9UU86; -.
DR   EnsemblFungi; SPCC1827.07c.1; SPCC1827.07c.1:pep; SPCC1827.07c.
DR   GeneID; 3361154; -.
DR   KEGG; spo:SPCC1827.07c; -.
DR   PomBase; SPCC1827.07c; -.
DR   VEuPathDB; FungiDB:SPCC1827.07c; -.
DR   eggNOG; KOG1162; Eukaryota.
DR   HOGENOM; CLU_006116_1_2_1; -.
DR   InParanoid; Q9UU86; -.
DR   OMA; GNWTEAR; -.
DR   PhylomeDB; Q9UU86; -.
DR   PRO; PR:Q9UU86; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR   GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR   GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0016036; P:cellular response to phosphate starvation; IBA:GO_Central.
DR   GO; GO:0006817; P:phosphate ion transport; IBA:GO_Central.
DR   GO; GO:0009966; P:regulation of signal transduction; ISM:PomBase.
DR   InterPro; IPR004342; EXS_C.
DR   InterPro; IPR004331; SPX_dom.
DR   InterPro; IPR033507; Syg1.
DR   PANTHER; PTHR10783:SF4; PTHR10783:SF4; 1.
DR   Pfam; PF03124; EXS; 1.
DR   Pfam; PF03105; SPX; 2.
DR   PROSITE; PS51380; EXS; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..682
FT                   /note="Protein SYG1 homolog"
FT                   /id="PRO_0000116894"
FT   TOPO_DOM        1..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..300
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        322..348
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        370..377
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        399..406
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        425..426
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        448..525
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        526..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        547..571
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        572..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        593..682
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..219
FT                   /note="SPX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT   DOMAIN          459..654
FT                   /note="EXS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00712"
FT   REGION          659..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   682 AA;  80591 MW;  2D7C7D3BA729EC0C CRC64;
     MKFGKVIEGQ SVAEWASAYF DYKKGKKIIA GIAKNPSEGL YGTSGILGET PEEAIVKRGQ
     IHRFHPLFQE FLDQQANKVE EFFENLVSDA RERMDLISDQ VDIYEKLRAF KKGTLESGSV
     VLIQKQHSKL RQRLDSILNF SRLQPAYHIP ARKSVPTDAY TPMVSYRKLK SKLKTTLLDF
     YDYLKLVSQY QHLNQQAFRK IVKKYDKTLH TDLQGFWVDY MSRYTFTDFS ITTNWQLHVE
     DIYARLFTNH NKKLALEHLK SFRQKEHFSA NSMRFGLLFG AGLPLAIEAA CYYNATEQSS
     YLLQIWGGFF LVIFAFVLFD LDCYVWEKTR VNYMLIFEFN QRKSLNWRQH LEIVGAVFFI
     FSLFFFLCMR NFFPGFTIYF PALFLGVVGT FLIAPVIVPY WRMRRYLIIQ LIRVFLSGLS
     TVHFQDFFFA DQMVSLTYAC GNISLFFCLY KRLWRQPQLC NSSHSPLLGF FTTLPGILRV
     FQCFRRYSDS LKSFPHLVNA LKYIFNILAQ MFLSLWRIHP GLKYRVLYTI FAGVNSLFSY
     TWDILMDWNL LVRKDGRWQF REHRILKQLW PYIIAMILNF IVRSSFIFYC IFPNHIQHSS
     GISFFVTLAE IMRRCMWNIL RVEHEEIYNR ENLRAARELK PLDFVKPHSD VFVSHQISSD
     KNYTDDEDSM DDQTDVDEAQ FS