BL1S1_ARATH
ID BL1S1_ARATH Reviewed; 152 AA.
AC O22929; Q0WNC8;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 1;
DE Short=BLOC-1 subunit 1;
DE AltName: Full=GCN5-like protein 1;
DE AltName: Full=Protein RT14 homolog;
GN Name=BLOS1; Synonyms=GCN5L1; OrderedLocusNames=At2g30330;
GN ORFNames=T09D09.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION, INTERACTION WITH BLOS2 AND
RP SNX1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=20971704; DOI=10.1242/jcs.069732;
RA Cui Y., Li X., Chen Q., He X., Yang Q., Zhang A., Yu X., Chen H., Liu N.,
RA Xie Q., Yang W., Zuo J., Palme K., Li W.;
RT "BLOS1, a putative BLOC-1 subunit, interacts with SNX1 and modulates root
RT growth in Arabidopsis.";
RL J. Cell Sci. 123:3727-3733(2010).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1), a complex that mediates the vacuolar degradative
CC transport via the intracellular vesicle trafficking from the endosome
CC to the vacuole. Probably regulates the PIN1 and PIN2 homeostasis
CC through its interaction with SNX1. {ECO:0000269|PubMed:20971704}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) (By similarity). Interacts with BLOS2 and SNX1.
CC {ECO:0000250, ECO:0000269|PubMed:20971704}.
CC -!- INTERACTION:
CC O22929; Q9FG38: SNX1; NbExp=5; IntAct=EBI-4406998, EBI-1543026;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome
CC {ECO:0000269|PubMed:20971704}.
CC -!- TISSUE SPECIFICITY: Expressed in the whole plant (at protein level).
CC {ECO:0000269|PubMed:20971704}.
CC -!- DISRUPTION PHENOTYPE: Longer primary roots and more lateral roots in
CC the RNAi mutant. {ECO:0000269|PubMed:20971704}.
CC -!- SIMILARITY: Belongs to the BLOC1S1 family. {ECO:0000305}.
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DR EMBL; AC002338; AAC16935.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08371.1; -; Genomic_DNA.
DR EMBL; BT008561; AAP40388.1; -; mRNA.
DR EMBL; BT008702; AAP40508.1; -; mRNA.
DR EMBL; AK229517; BAF01372.1; -; mRNA.
DR PIR; B84707; B84707.
DR RefSeq; NP_180592.1; NM_128586.3.
DR AlphaFoldDB; O22929; -.
DR SMR; O22929; -.
DR BioGRID; 2932; 6.
DR IntAct; O22929; 3.
DR STRING; 3702.AT2G30330.1; -.
DR PaxDb; O22929; -.
DR PRIDE; O22929; -.
DR ProteomicsDB; 240770; -.
DR EnsemblPlants; AT2G30330.1; AT2G30330.1; AT2G30330.
DR GeneID; 817583; -.
DR Gramene; AT2G30330.1; AT2G30330.1; AT2G30330.
DR KEGG; ath:AT2G30330; -.
DR Araport; AT2G30330; -.
DR TAIR; locus:2065759; AT2G30330.
DR eggNOG; KOG3390; Eukaryota.
DR HOGENOM; CLU_115602_2_0_1; -.
DR InParanoid; O22929; -.
DR OMA; HSATNFA; -.
DR OrthoDB; 1603359at2759; -.
DR PhylomeDB; O22929; -.
DR PRO; PR:O22929; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22929; baseline and differential.
DR Genevisible; O22929; AT.
DR GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IDA:TAIR.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0045324; P:late endosome to vacuole transport; TAS:UniProtKB.
DR GO; GO:0048364; P:root development; IMP:UniProtKB.
DR InterPro; IPR009395; BLOC1S1.
DR PANTHER; PTHR13073; PTHR13073; 1.
DR Pfam; PF06320; GCN5L1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Endosome; Reference proteome.
FT CHAIN 1..152
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 1"
FT /id="PRO_0000156334"
SQ SEQUENCE 152 AA; 17378 MW; 7DA1A68FEE1D2403 CRC64;
MNTPMSLSAA RGRMLPFLEK EKSEEESETL ESSLLQLIDD NRRSSLQLRE KTERSRKEAI
RHAARTADLL VKAVNGGVEE CFVNEKRIES EIRNLAITVA KFGKQTDQWL AVTHAVNSAV
KEIGDFENWM KTMEFDCKKI TAAIRNIHED QQ
