ID   BL1S1_BOVIN             Reviewed;         125 AA.
AC   Q2NKW0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 1;
DE            Short=BLOC-1 subunit 1;
GN   Name=BLOC1S1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO), such as
CC       platelet dense granules and melanosomes. In concert with the AP-3
CC       complex, the BLOC-1 complex is required to target membrane protein
CC       cargos into vesicles assembled at cell bodies for delivery into
CC       neurites and nerve terminals. The BLOC-1 complex, in association with
CC       SNARE proteins, is also proposed to be involved in neurite extension.
CC       As part of the BORC complex may play a role in lysosomes movement and
CC       localization at the cell periphery. The BORC complex is most probably
CC       associated with the cytosolic face of lysosomes, may recruit ARL8B and
CC       couple lysosomes to microtubule plus-end-directed kinesin motor.
CC       {ECO:0000250|UniProtKB:P78537}.
CC   -!- FUNCTION: May negatively regulate aerobic respiration through
CC       mitochondrial protein lysine-acetylation. May counteract the action of
CC       the deacetylase SIRT3 by acetylating and regulating proteins of the
CC       mitochondrial respiratory chain including ATP5F1A and NDUFA9.
CC       {ECO:0000250|UniProtKB:P78537}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4,
CC       BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed
CC       of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6,
CC       DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with
CC       the AP-3 protein complex and membrane protein cargos. Component of the
CC       BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2,
CC       BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. Interacts with ATP5F1A
CC       and NDUFA9; involved in their acetylation on lysine residues. Interacts
CC       with KXD1. {ECO:0000250|UniProtKB:O55102,
CC       ECO:0000250|UniProtKB:P78537}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space
CC       {ECO:0000250|UniProtKB:P78537}. Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:P78537}. Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P78537}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:P78537}.
CC   -!- SIMILARITY: Belongs to the BLOC1S1 family. {ECO:0000305}.
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DR   EMBL; BC111605; AAI11606.1; -; mRNA.
DR   RefSeq; NP_001069830.1; NM_001076362.2.
DR   AlphaFoldDB; Q2NKW0; -.
DR   SMR; Q2NKW0; -.
DR   STRING; 9913.ENSBTAP00000015810; -.
DR   PaxDb; Q2NKW0; -.
DR   PRIDE; Q2NKW0; -.
DR   Ensembl; ENSBTAT00000015810; ENSBTAP00000015810; ENSBTAG00000011918.
DR   GeneID; 615149; -.
DR   KEGG; bta:615149; -.
DR   CTD; 2647; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011918; -.
DR   eggNOG; KOG3390; Eukaryota.
DR   GeneTree; ENSGT00390000002689; -.
DR   HOGENOM; CLU_115602_3_0_1; -.
DR   InParanoid; Q2NKW0; -.
DR   OMA; HSATNFA; -.
DR   OrthoDB; 1603359at2759; -.
DR   TreeFam; TF314443; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000011918; Expressed in pons and 107 other tissues.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0009060; P:aerobic respiration; ISS:UniProtKB.
DR   GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR   GO; GO:0018394; P:peptidyl-lysine acetylation; ISS:UniProtKB.
DR   InterPro; IPR009395; BLOC1S1.
DR   PANTHER; PTHR13073; PTHR13073; 1.
DR   Pfam; PF06320; GCN5L1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Lysosome; Membrane; Mitochondrion;
KW   Reference proteome.
FT   CHAIN           1..125
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 1"
FT                   /id="PRO_0000342160"
FT   COILED          1..31
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   125 AA;  14311 MW;  68E3FA07A0A4ECED CRC64;
     MLSRLLKEHQ AKQNERKELQ EKRRREAITA ATCLTEALVD HLNVGVAQAY MNQRKLDHEV
     KTLQVQAAQF AKQTGQWIGM VENFNQALKE IGDVENWARS IELDMRTIAT ALEYVYKGQL
     QSAPS