ID   BL1S1_CAEEL             Reviewed;         129 AA.
AC   Q22616;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 1;
DE            Short=BLOC-1 subunit 1;
GN   Name=blos-1; ORFNames=T20G5.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION, AND INTERACTION WITH GLO-2.
RX   PubMed=22916203; DOI=10.1371/journal.pone.0043043;
RA   Hermann G.J., Scavarda E., Weis A.M., Saxton D.S., Thomas L.L., Salesky R.,
RA   Somhegyi H., Curtin T.P., Barrett A., Foster O.K., Vine A., Erlich K.,
RA   Kwan E., Rabbitts B.M., Warren K.;
RT   "C. elegans BLOC-1 Functions in Trafficking to Lysosome-Related Gut
RT   Granules.";
RL   PLoS ONE 7:E43043-E43043(2012).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1), a complex involved in gut granule biogenesis. May
CC       negatively regulate aerobic respiration through mitochondrial protein
CC       lysine-acetylation. {ECO:0000269|PubMed:22916203}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1,
CC       glo-2, mutd-1 and snpn-1. Interacts with glo-2.
CC       {ECO:0000269|PubMed:22916203}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC       Mitochondrion matrix {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BLOC1S1 family. {ECO:0000305}.
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DR   EMBL; Z30423; CAA83011.1; -; Genomic_DNA.
DR   PIR; S42377; S42377.
DR   RefSeq; NP_499262.2; NM_066861.4.
DR   AlphaFoldDB; Q22616; -.
DR   SMR; Q22616; -.
DR   BioGRID; 41629; 3.
DR   ComplexPortal; CPX-479; Bloc-1 complex.
DR   DIP; DIP-25647N; -.
DR   IntAct; Q22616; 1.
DR   STRING; 6239.T20G5.10; -.
DR   EPD; Q22616; -.
DR   PaxDb; Q22616; -.
DR   PeptideAtlas; Q22616; -.
DR   EnsemblMetazoa; T20G5.10.1; T20G5.10.1; WBGene00011872.
DR   GeneID; 176435; -.
DR   KEGG; cel:CELE_T20G5.10; -.
DR   UCSC; T20G5.10; c. elegans.
DR   CTD; 176435; -.
DR   WormBase; T20G5.10; CE51581; WBGene00011872; blos-1.
DR   eggNOG; KOG3390; Eukaryota.
DR   GeneTree; ENSGT00390000002689; -.
DR   HOGENOM; CLU_115602_3_0_1; -.
DR   InParanoid; Q22616; -.
DR   OMA; HSATNFA; -.
DR   OrthoDB; 1603359at2759; -.
DR   PhylomeDB; Q22616; -.
DR   Reactome; R-CEL-432720; Lysosome Vesicle Biogenesis.
DR   PRO; PR:Q22616; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00011872; Expressed in embryo and 4 other tissues.
DR   GO; GO:0031082; C:BLOC complex; IC:ComplexPortal.
DR   GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0016197; P:endosomal transport; IMP:UniProtKB.
DR   GO; GO:1904757; P:positive regulation of gut granule assembly; IC:ComplexPortal.
DR   InterPro; IPR009395; BLOC1S1.
DR   PANTHER; PTHR13073; PTHR13073; 1.
DR   Pfam; PF06320; GCN5L1; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Mitochondrion; Reference proteome.
FT   CHAIN           1..129
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 1"
FT                   /id="PRO_0000156335"
SQ   SEQUENCE   129 AA;  14676 MW;  5754476CE495CEE5 CRC64;
     MLKEHSKKQH LRREVQEKLK NEAIVAAQTL STAVVDHLNA KVAQAYGNQK RLDVEAKRFE
     NNSAALAKQT EQWLFITEGL NYALKEIGDV ENWSKTIEND MKIITETLRR AYEAKNPPLP
     PNQANPASH