ID   BL1S1_DICDI             Reviewed;         135 AA.
AC   Q54VX7;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 1;
DE            Short=BLOC-1 subunit 1;
GN   Name=bloc1s1; ORFNames=DDB_G0280077;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO). May also
CC       participate in the coupling of lysosomes to microtubule plus-end-
CC       directed kinesin motor. May also play a role in intracellular vesicle
CC       trafficking. {ECO:0000250|UniProtKB:P78537}.
CC   -!- FUNCTION: May negatively regulate aerobic respiration through
CC       mitochondrial protein lysine-acetylation.
CC       {ECO:0000250|UniProtKB:P78537}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1). {ECO:0000250|UniProtKB:P78537}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space
CC       {ECO:0000250|UniProtKB:P78537}. Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:P78537}. Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P78537}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:P78537}.
CC   -!- SIMILARITY: Belongs to the BLOC1S1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000035; EAL67265.1; -; Genomic_DNA.
DR   RefSeq; XP_641228.1; XM_636136.1.
DR   AlphaFoldDB; Q54VX7; -.
DR   SMR; Q54VX7; -.
DR   STRING; 44689.DDB0231752; -.
DR   PaxDb; Q54VX7; -.
DR   EnsemblProtists; EAL67265; EAL67265; DDB_G0280077.
DR   GeneID; 8622359; -.
DR   KEGG; ddi:DDB_G0280077; -.
DR   dictyBase; DDB_G0280077; bloc1s1.
DR   eggNOG; KOG3390; Eukaryota.
DR   HOGENOM; CLU_115602_3_0_1; -.
DR   InParanoid; Q54VX7; -.
DR   OMA; HSATNFA; -.
DR   PhylomeDB; Q54VX7; -.
DR   PRO; PR:Q54VX7; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   InterPro; IPR009395; BLOC1S1.
DR   PANTHER; PTHR13073; PTHR13073; 1.
DR   Pfam; PF06320; GCN5L1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Lysosome; Membrane; Mitochondrion;
KW   Reference proteome.
FT   CHAIN           1..135
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 1"
FT                   /id="PRO_0000342161"
FT   COILED          1..27
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   135 AA;  15485 MW;  F42DD707C32E4E4E CRC64;
     MLSKLVKDHQ THQNKLKEEN EVLKKEAIAS MGVVTNGLID SVNTGVACIF ANQKKLETEA
     RLLQANTAKF SKQTNQWIHL IENFNNSLKE IGDVENWSKK IESDMHNISD IIEFLYINSN
     PIQQQPQQQP QQQQQ