BL1S1_DROME
ID BL1S1_DROME Reviewed; 147 AA.
AC A1Z9S1;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 1;
DE Short=BLOC-1 subunit 1;
GN Name=Blos1 {ECO:0000312|FlyBase:FBgn0050077};
GN Synonyms=CG30077 {ECO:0000312|FlyBase:FBgn0050077};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION, INTERACTION WITH PLDN, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=20015953; DOI=10.1093/hmg/ddp555;
RA Cheli V.T., Daniels R.W., Godoy R., Hoyle D.J., Kandachar V., Starcevic M.,
RA Martinez-Agosto J.A., Poole S., DiAntonio A., Lloyd V.K., Chang H.C.,
RA Krantz D.E., Dell'Angelica E.C.;
RT "Genetic modifiers of abnormal organelle biogenesis in a Drosophila model
RT of BLOC-1 deficiency.";
RL Hum. Mol. Genet. 19:861-878(2010).
RN [4]
RP FUNCTION.
RX PubMed=28317021; DOI=10.1523/eneuro.0335-16.2017;
RA Chen X., Ma W., Zhang S., Paluch J., Guo W., Dickman D.K.;
RT "The BLOC-1 Subunit Pallidin Facilitates Activity-Dependent Synaptic
RT Vesicle Recycling.";
RL ENeuro 4:0-0(2017).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane
CC trafficking in synapses (PubMed:20015953, PubMed:28317021). In response
CC to high synaptic activity at neuromuscular junctions, stabilizes Pldn
CC protein levels and, together with Pldn, plays a role in promoting
CC efficient synaptic vesicle recycling and re-formation through early
CC endosomes (PubMed:28317021). {ECO:0000269|PubMed:20015953,
CC ECO:0000269|PubMed:28317021}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4, Dysb, Muted,
CC Pldn and Snapin. Interacts with Pldn. {ECO:0000269|PubMed:20015953}.
CC -!- DISRUPTION PHENOTYPE: Show reduced eye pigmentation.
CC {ECO:0000269|PubMed:20015953}.
CC -!- SIMILARITY: Belongs to the BLOC1S1 family. {ECO:0000305}.
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DR EMBL; AE013599; AAM68556.2; -; Genomic_DNA.
DR RefSeq; NP_725401.2; NM_166060.3.
DR AlphaFoldDB; A1Z9S1; -.
DR SMR; A1Z9S1; -.
DR BioGRID; 73022; 64.
DR IntAct; A1Z9S1; 47.
DR STRING; 7227.FBpp0290948; -.
DR PaxDb; A1Z9S1; -.
DR EnsemblMetazoa; FBtr0301734; FBpp0290948; FBgn0050077.
DR GeneID; 246439; -.
DR KEGG; dme:Dmel_CG30077; -.
DR UCSC; CG30077-RA; d. melanogaster.
DR CTD; 246439; -.
DR FlyBase; FBgn0050077; Blos1.
DR VEuPathDB; VectorBase:FBgn0050077; -.
DR eggNOG; KOG3390; Eukaryota.
DR GeneTree; ENSGT00390000002689; -.
DR HOGENOM; CLU_115602_3_0_1; -.
DR InParanoid; A1Z9S1; -.
DR OMA; HSATNFA; -.
DR OrthoDB; 1603359at2759; -.
DR PhylomeDB; A1Z9S1; -.
DR Reactome; R-DME-432720; Lysosome Vesicle Biogenesis.
DR BioGRID-ORCS; 246439; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 246439; -.
DR PRO; PR:A1Z9S1; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0050077; Expressed in mouthpart and 23 other tissues.
DR ExpressionAtlas; A1Z9S1; baseline and differential.
DR Genevisible; A1Z9S1; DM.
DR GO; GO:0031083; C:BLOC-1 complex; IGI:FlyBase.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0061909; P:autophagosome-lysosome fusion; IMP:FlyBase.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0008057; P:eye pigment granule organization; IMP:FlyBase.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase.
DR GO; GO:0008355; P:olfactory learning; IMP:FlyBase.
DR GO; GO:0050808; P:synapse organization; IMP:FlyBase.
DR GO; GO:0036466; P:synaptic vesicle recycling via endosome; IMP:FlyBase.
DR GO; GO:0048489; P:synaptic vesicle transport; IMP:FlyBase.
DR InterPro; IPR009395; BLOC1S1.
DR PANTHER; PTHR13073; PTHR13073; 1.
DR Pfam; PF06320; GCN5L1; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..147
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 1"
FT /id="PRO_0000420192"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 147 AA; 16153 MW; C75BF153DACDE731 CRC64;
MLTSMVKEHH KEQAKRKQEQ EVRRKEAIEA SNELTQSLVD TLNVGVAQAY LNQKRLDAEA
KQLHLGATNF AKQTHQWLQL IDQFSTALKD LGDVENWARS IEGDMHTINQ TLELAYKASR
ATQTSSGAGT SLEASTSASA SANPSAT
