BL1S1_XENTR
ID BL1S1_XENTR Reviewed; 125 AA.
AC Q0VFD8;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 1;
DE Short=BLOC-1 subunit 1;
GN Name=bloc1s1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=N6; TISSUE=Skeletal muscle;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO), such as
CC platelet dense granules and melanosomes. May also play a role in
CC intracellular vesicle trafficking. As part of a BORC-like complex may
CC play a role in lysosomes movement and localization at the cell
CC periphery. Associated with the cytosolic face of lysosomes, this
CC complex may couple lysosomes to microtubule plus-end-directed kinesin
CC motor. {ECO:0000250|UniProtKB:P78537}.
CC -!- FUNCTION: May negatively regulate aerobic respiration through
CC mitochondrial protein lysine-acetylation.
CC {ECO:0000250|UniProtKB:P78537}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex 1 (BLOC-1). {ECO:0000250|UniProtKB:P78537}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space
CC {ECO:0000250|UniProtKB:P78537}. Mitochondrion matrix
CC {ECO:0000250|UniProtKB:P78537}. Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P78537}. Lysosome membrane
CC {ECO:0000250|UniProtKB:P78537}.
CC -!- SIMILARITY: Belongs to the BLOC1S1 family. {ECO:0000305}.
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DR EMBL; AAMC01034982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01034983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01034984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC118866; AAI18867.1; -; mRNA.
DR RefSeq; NP_001072249.1; NM_001078781.1.
DR AlphaFoldDB; Q0VFD8; -.
DR SMR; Q0VFD8; -.
DR STRING; 8364.ENSXETP00000016095; -.
DR PaxDb; Q0VFD8; -.
DR DNASU; 779698; -.
DR GeneID; 779698; -.
DR KEGG; xtr:779698; -.
DR CTD; 2647; -.
DR Xenbase; XB-GENE-952074; bloc1s1.
DR eggNOG; KOG3390; Eukaryota.
DR HOGENOM; CLU_115602_3_0_1; -.
DR InParanoid; Q0VFD8; -.
DR OMA; THAMNSA; -.
DR OrthoDB; 1603359at2759; -.
DR PhylomeDB; Q0VFD8; -.
DR TreeFam; TF314443; -.
DR Reactome; R-XTR-432720; Lysosome Vesicle Biogenesis.
DR Proteomes; UP000008143; Chromosome 2.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000017483; Expressed in heart and 13 other tissues.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; ISS:UniProtKB.
DR GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0018394; P:peptidyl-lysine acetylation; ISS:UniProtKB.
DR InterPro; IPR009395; BLOC1S1.
DR PANTHER; PTHR13073; PTHR13073; 1.
DR Pfam; PF06320; GCN5L1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Lysosome; Membrane; Mitochondrion;
KW Reference proteome.
FT CHAIN 1..125
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 1"
FT /id="PRO_0000416772"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..25
FT /evidence="ECO:0000255"
FT COMPBIAS 8..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 125 AA; 14221 MW; 821A59A098A91CE2 CRC64;
MLSRLLKEHQ GKQTERKEAQ EKRRKDAIAA ATTLTEALVD HLNVGVAQAY VNQRKLDHEV
KTLQTQAAQF AKQTTQWISL VENFNQALKE IGDVENWARS IEKDMRIIAT ALEYVYKGQL
QPSAS
