ID   BL1S2_ARATH             Reviewed;         127 AA.
AC   F4K657; Q570L7; Q8LBQ0; Q9FGZ1;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 2;
DE            Short=BLOC-1 subunit 2;
GN   Name=BLOS2; OrderedLocusNames=At5g49550; ORFNames=K6M13.19;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION, AND INTERACTION WITH BLOS1
RP   AND SNX1.
RX   PubMed=20971704; DOI=10.1242/jcs.069732;
RA   Cui Y., Li X., Chen Q., He X., Yang Q., Zhang A., Yu X., Chen H., Liu N.,
RA   Xie Q., Yang W., Zuo J., Palme K., Li W.;
RT   "BLOS1, a putative BLOC-1 subunit, interacts with SNX1 and modulates root
RT   growth in Arabidopsis.";
RL   J. Cell Sci. 123:3727-3733(2010).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1), a complex that mediates the vacuolar degradative
CC       transport via the intracellular vesicle trafficking from the endosome
CC       to the vacuole. {ECO:0000269|PubMed:20971704}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) (By similarity). Interacts with BLOS1 and SNX1.
CC       {ECO:0000250, ECO:0000269|PubMed:20971704}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BLOC1S2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB10768.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At5g49550 and At5g49555.; Evidence={ECO:0000305};
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DR   EMBL; AB023033; BAB10768.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED95828.1; -; Genomic_DNA.
DR   EMBL; AK220691; BAD93768.1; -; mRNA.
DR   EMBL; AY087067; AAM64628.1; -; mRNA.
DR   RefSeq; NP_568711.1; NM_124332.3.
DR   AlphaFoldDB; F4K657; -.
DR   SMR; F4K657; -.
DR   BioGRID; 20262; 1.
DR   IntAct; F4K657; 2.
DR   STRING; 3702.AT5G49550.1; -.
DR   PaxDb; F4K657; -.
DR   PRIDE; F4K657; -.
DR   ProteomicsDB; 240732; -.
DR   EnsemblPlants; AT5G49550.1; AT5G49550.1; AT5G49550.
DR   GeneID; 835016; -.
DR   Gramene; AT5G49550.1; AT5G49550.1; AT5G49550.
DR   KEGG; ath:AT5G49550; -.
DR   Araport; AT5G49550; -.
DR   TAIR; locus:2157854; AT5G49550.
DR   eggNOG; KOG4254; Eukaryota.
DR   HOGENOM; CLU_132900_0_0_1; -.
DR   InParanoid; F4K657; -.
DR   OMA; CSDMFEK; -.
DR   OrthoDB; 1463654at2759; -.
DR   PRO; PR:F4K657; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4K657; baseline and differential.
DR   Genevisible; F4K657; AT.
DR   GO; GO:0031083; C:BLOC-1 complex; TAS:UniProtKB.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019269; BLOC1_su2.
DR   Pfam; PF10046; BLOC1_2; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Endosome; Reference proteome.
FT   CHAIN           1..127
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 2"
FT                   /id="PRO_0000414727"
FT   CONFLICT        44
FT                   /note="V -> I (in Ref. 4; AAM64628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        58
FT                   /note="L -> P (in Ref. 3; BAD93768)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        121
FT                   /note="N -> I (in Ref. 4; AAM64628)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   127 AA;  14266 MW;  CA6180EED7CD2580 CRC64;
     MADSRDDLAE SLQNLFTSVS SMVKSELQGT NNHLDLLEKM NLRVASEYDD MGDVAAGLRV
     FAEQMKSKSG GLDEFVGQMD AIEKQVSEFE AVISVLDRYV SVLESKIRAE YRHPHHQRRS
     NDSVVTD