BL1S2_CAEEL
ID BL1S2_CAEEL Reviewed; 132 AA.
AC Q95XD3;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 2;
DE Short=BLOC-1 subunit 2;
GN Name=blos-2; ORFNames=Y73B6BL.30;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, AND FUNCTION.
RX PubMed=22916203; DOI=10.1371/journal.pone.0043043;
RA Hermann G.J., Scavarda E., Weis A.M., Saxton D.S., Thomas L.L., Salesky R.,
RA Somhegyi H., Curtin T.P., Barrett A., Foster O.K., Vine A., Erlich K.,
RA Kwan E., Rabbitts B.M., Warren K.;
RT "C. elegans BLOC-1 Functions in Trafficking to Lysosome-Related Gut
RT Granules.";
RL PLoS ONE 7:E43043-E43043(2012).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in gut granule biogenesis.
CC {ECO:0000269|PubMed:22916203}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1,
CC glo-2, mutd-1 and snpn-1. {ECO:0000269|PubMed:22916203}.
CC -!- SIMILARITY: Belongs to the BLOC1S2 family. {ECO:0000305}.
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DR EMBL; FO081731; CCD74176.1; -; Genomic_DNA.
DR RefSeq; NP_500967.1; NM_068566.5.
DR AlphaFoldDB; Q95XD3; -.
DR SMR; Q95XD3; -.
DR ComplexPortal; CPX-479; Bloc-1 complex.
DR STRING; 6239.Y73B6BL.30; -.
DR EPD; Q95XD3; -.
DR PaxDb; Q95XD3; -.
DR PeptideAtlas; Q95XD3; -.
DR EnsemblMetazoa; Y73B6BL.30a.1; Y73B6BL.30a.1; WBGene00022251.
DR GeneID; 177395; -.
DR KEGG; cel:CELE_Y73B6BL.30; -.
DR UCSC; Y73B6BL.30; c. elegans.
DR CTD; 177395; -.
DR WormBase; Y73B6BL.30a; CE29005; WBGene00022251; blos-2.
DR eggNOG; KOG4559; Eukaryota.
DR HOGENOM; CLU_110820_2_0_1; -.
DR InParanoid; Q95XD3; -.
DR OMA; CSDMFEK; -.
DR OrthoDB; 1505524at2759; -.
DR PhylomeDB; Q95XD3; -.
DR PRO; PR:Q95XD3; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00022251; Expressed in embryo and 3 other tissues.
DR ExpressionAtlas; Q95XD3; baseline and differential.
DR GO; GO:0031082; C:BLOC complex; IC:ComplexPortal.
DR GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR GO; GO:0099078; C:BORC complex; IBA:GO_Central.
DR GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IMP:UniProtKB.
DR GO; GO:0032418; P:lysosome localization; IBA:GO_Central.
DR GO; GO:1904757; P:positive regulation of gut granule assembly; IC:ComplexPortal.
DR InterPro; IPR019269; BLOC1_su2.
DR PANTHER; PTHR46479; PTHR46479; 1.
DR Pfam; PF10046; BLOC1_2; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..132
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 2"
FT /id="PRO_0000420194"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 132 AA; 14999 MW; 0750E7F0C309B4CB CRC64;
MAEINERAST SSPPVPSTPA PVPHIRQLAD NMTDKVGQFF QHQLEGSIEE YKLLETMNNT
TAQRYVDMKV VAEKVAGKLD NLNQKYENLR PYLSQIDAMD ESTRRLEEAT AVLENYVTQL
ESKLTNIQQQ SQ
