ID   BL1S2_DICDI             Reviewed;         234 AA.
AC   Q54Y67;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 2;
DE            Short=BLOC-1 subunit 2;
GN   Name=bloc1s2; ORFNames=DDB_G0278387;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO). May also
CC       participate in the coupling of lysosomes to microtubule plus-end-
CC       directed kinesin motor. May also play a role in intracellular vesicle
CC       trafficking. {ECO:0000250|UniProtKB:Q6QNY1}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1). {ECO:0000250|UniProtKB:Q6QNY1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q6QNY1}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:Q6QNY1}.
CC   -!- SIMILARITY: Belongs to the BLOC1S2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL68366.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAFI02000023; EAL68366.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_642335.1; XM_637243.1.
DR   AlphaFoldDB; Q54Y67; -.
DR   SMR; Q54Y67; -.
DR   STRING; 44689.DDB0302513; -.
DR   PaxDb; Q54Y67; -.
DR   EnsemblProtists; EAL68366; EAL68366; DDB_G0278387.
DR   GeneID; 8621541; -.
DR   KEGG; ddi:DDB_G0278387; -.
DR   dictyBase; DDB_G0278387; bloc1s2.
DR   eggNOG; KOG4559; Eukaryota.
DR   InParanoid; Q54Y67; -.
DR   PRO; PR:Q54Y67; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR   GO; GO:0099078; C:BORC complex; IBA:GO_Central.
DR   GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:0032418; P:lysosome localization; IBA:GO_Central.
DR   InterPro; IPR019269; BLOC1_su2.
DR   PANTHER; PTHR46479; PTHR46479; 1.
DR   Pfam; PF10046; BLOC1_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Lysosome; Membrane;
KW   Reference proteome.
FT   CHAIN           1..234
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 2"
FT                   /id="PRO_0000342163"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          145..184
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        191..212
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   234 AA;  26616 MW;  5869CB8B6BF3A2E3 CRC64;
     MSETTPNNTS NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNHNNNNN TNNNNIDTFS
     QKASNDIVKP ILPVTEDLQN STKEMFTKVS SYIKSELATT VSDYNLLIQM NNITSSKYQD
     MTNVTKGLSV FMGDLKIKYE EFQPYFDKIN ELDKNVTDLE KTVQLLDEYT KRLEQKVKNI
     DKSSLLPTKQ IQPPQPIPQQ QPAQPAQPTQ PTQPAQQPSQ VSTETKPQEN IENK