BL1S2_DROME
ID BL1S2_DROME Reviewed; 159 AA.
AC Q9VTE0;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 2;
DE Short=BLOC-1 subunit 2;
GN Name=Blos2 {ECO:0000312|FlyBase:FBgn0036118};
GN ORFNames=CG14145 {ECO:0000312|FlyBase:FBgn0036118};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION, HOMODIMERIZATION, AND
RP INTERACTION WITH SNAPIN.
RX PubMed=20015953; DOI=10.1093/hmg/ddp555;
RA Cheli V.T., Daniels R.W., Godoy R., Hoyle D.J., Kandachar V., Starcevic M.,
RA Martinez-Agosto J.A., Poole S., DiAntonio A., Lloyd V.K., Chang H.C.,
RA Krantz D.E., Dell'Angelica E.C.;
RT "Genetic modifiers of abnormal organelle biogenesis in a Drosophila model
RT of BLOC-1 deficiency.";
RL Hum. Mol. Genet. 19:861-878(2010).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in pigment granule biogenesis.
CC {ECO:0000269|PubMed:20015953}.
CC -!- SUBUNIT: Homodimer. Component of the biogenesis of lysosome-related
CC organelles complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4,
CC Dysb, Muted, Pldn and Snapin. Interacts with Snapin.
CC {ECO:0000269|PubMed:20015953}.
CC -!- SIMILARITY: Belongs to the BLOC1S2 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF50112.2; -; Genomic_DNA.
DR EMBL; BT023680; AAY85080.1; -; mRNA.
DR RefSeq; NP_648427.1; NM_140170.2.
DR AlphaFoldDB; Q9VTE0; -.
DR SMR; Q9VTE0; -.
DR BioGRID; 64610; 32.
DR IntAct; Q9VTE0; 13.
DR STRING; 7227.FBpp0075932; -.
DR PaxDb; Q9VTE0; -.
DR DNASU; 39234; -.
DR EnsemblMetazoa; FBtr0076202; FBpp0075932; FBgn0036118.
DR GeneID; 39234; -.
DR KEGG; dme:Dmel_CG14145; -.
DR UCSC; CG14145-RA; d. melanogaster.
DR CTD; 39234; -.
DR FlyBase; FBgn0036118; Blos2.
DR VEuPathDB; VectorBase:FBgn0036118; -.
DR eggNOG; KOG4559; Eukaryota.
DR GeneTree; ENSGT00390000005889; -.
DR HOGENOM; CLU_110820_1_0_1; -.
DR InParanoid; Q9VTE0; -.
DR OMA; QNTYADF; -.
DR OrthoDB; 1505524at2759; -.
DR PhylomeDB; Q9VTE0; -.
DR SignaLink; Q9VTE0; -.
DR BioGRID-ORCS; 39234; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 39234; -.
DR PRO; PR:Q9VTE0; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036118; Expressed in saliva-secreting gland and 27 other tissues.
DR ExpressionAtlas; Q9VTE0; baseline and differential.
DR Genevisible; Q9VTE0; DM.
DR GO; GO:0031083; C:BLOC-1 complex; ISS:FlyBase.
DR GO; GO:0099078; C:BORC complex; IBA:GO_Central.
DR GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0061909; P:autophagosome-lysosome fusion; IMP:FlyBase.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0032418; P:lysosome localization; IBA:GO_Central.
DR InterPro; IPR019269; BLOC1_su2.
DR PANTHER; PTHR46479; PTHR46479; 1.
DR Pfam; PF10046; BLOC1_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..159
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 2"
FT /id="PRO_0000420193"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 69..134
FT /evidence="ECO:0000255"
SQ SEQUENCE 159 AA; 17564 MW; 38C9765209EE2312 CRC64;
MDKPTTSAAA AAAQDSNLLP DSPQHGPTLS SASSFEALTR HDPNLSRLAT KMFNKTEEYI
THELNAPLED YKLLEEMNKA TIAKYKDMRQ IAENLNTSTS ELSLKFQQLA PMMQQIDEIS
DTVDKLEAAA YKLDAYSIAL ENRVKCVLQR KSGGGQVAQ
