ID   BL1S2_MACFA             Reviewed;         142 AA.
AC   Q4R7C8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 2;
DE            Short=BLOC-1 subunit 2;
GN   Name=BLOC1S2; ORFNames=QtsA-15578;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO), such as
CC       platelet dense granules and melanosomes. In concert with the AP-3
CC       complex, the BLOC-1 complex is required to target membrane protein
CC       cargos into vesicles assembled at cell bodies for delivery into
CC       neurites and nerve terminals. The BLOC-1 complex, in association with
CC       SNARE proteins, is also proposed to be involved in neurite extension.
CC       As part of the BORC complex may play a role in lysosomes movement and
CC       localization at the cell periphery. Associated with the cytosolic face
CC       of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes
CC       to microtubule plus-end-directed kinesin motor. May play a role in cell
CC       proliferation. {ECO:0000250|UniProtKB:Q6QNY1,
CC       ECO:0000250|UniProtKB:Q9CWG9}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4,
CC       BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed
CC       of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6,
CC       DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly with BLOC1S1,
CC       BLOC1S3, BLOC1S4, BLOC1S5 and SNAPIN. The BLOC-1 complex associates
CC       with the AP-3 protein complex and membrane protein cargos. Component of
CC       the BLOC-one-related complex (BORC) which is composed of BLOC1S1,
CC       BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. Interacts
CC       with gamma-tubulin. Interacts with IFT57.
CC       {ECO:0000250|UniProtKB:Q6QNY1, ECO:0000250|UniProtKB:Q9CWG9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q6QNY1}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:Q6QNY1}. Note=Localizes to the centrosomes in a
CC       microtubule-dependent manner. {ECO:0000250|UniProtKB:Q6QNY1}.
CC   -!- SIMILARITY: Belongs to the BLOC1S2 family. {ECO:0000305}.
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DR   EMBL; AB168891; BAE00994.1; -; mRNA.
DR   RefSeq; NP_001274664.1; NM_001287735.1.
DR   AlphaFoldDB; Q4R7C8; -.
DR   SMR; Q4R7C8; -.
DR   STRING; 9541.XP_005566246.1; -.
DR   GeneID; 102120191; -.
DR   CTD; 282991; -.
DR   VEuPathDB; HostDB:ENSMFAG00000041054; -.
DR   eggNOG; KOG4559; Eukaryota.
DR   OrthoDB; 1505524at2759; -.
DR   Proteomes; UP000233100; Chromosome 9.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR   InterPro; IPR019269; BLOC1_su2.
DR   PANTHER; PTHR46479; PTHR46479; 1.
DR   Pfam; PF10046; BLOC1_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Cytoplasm; Cytoskeleton; Lysosome; Membrane;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q6QNY1"
FT   CHAIN           2..142
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 2"
FT                   /id="PRO_0000234544"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          79..127
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        11..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6QNY1"
SQ   SEQUENCE   142 AA;  16020 MW;  F5ED2EADD43190FA CRC64;
     MAAAAEGVLA TRRDESARDD AAVETAEEAK EPAEADITEL CRDMFSKMAT YLTGELTATS
     EDYKLLENMN KLTSLKYLEM KDIAINISRN LKDLNQKYAG LQPYLDQINV IEEQVAALEQ
     AAYKLDAYSK KLEAKYKKLE KR