BL1S2_NEMVE
ID BL1S2_NEMVE Reviewed; 171 AA.
AC A7RZS0;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 2;
DE Short=BLOC-1 subunit 2;
GN Name=bloc1s2; ORFNames=v1g241820;
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6;
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO). May also
CC participate in the coupling of lysosomes to microtubule plus-end-
CC directed kinesin motor. May also play a role in intracellular vesicle
CC trafficking. {ECO:0000250|UniProtKB:Q6QNY1}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex 1 (BLOC-1). {ECO:0000250|UniProtKB:Q6QNY1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q6QNY1}. Lysosome membrane
CC {ECO:0000250|UniProtKB:Q6QNY1}.
CC -!- SIMILARITY: Belongs to the BLOC1S2 family. {ECO:0000305}.
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DR EMBL; DS469558; EDO42993.1; -; Genomic_DNA.
DR RefSeq; XP_001635056.1; XM_001635006.1.
DR AlphaFoldDB; A7RZS0; -.
DR SMR; A7RZS0; -.
DR STRING; 45351.EDO42993; -.
DR EnsemblMetazoa; EDO42993; EDO42993; NEMVEDRAFT_v1g241820.
DR eggNOG; KOG4559; Eukaryota.
DR HOGENOM; CLU_110820_0_0_1; -.
DR InParanoid; A7RZS0; -.
DR OMA; MEPEADI; -.
DR OrthoDB; 1505524at2759; -.
DR PhylomeDB; A7RZS0; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR GO; GO:0099078; C:BORC complex; IBA:GO_Central.
DR GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0032418; P:lysosome localization; IBA:GO_Central.
DR InterPro; IPR019269; BLOC1_su2.
DR PANTHER; PTHR46479; PTHR46479; 1.
DR Pfam; PF10046; BLOC1_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Cytoskeleton; Lysosome; Membrane;
KW Reference proteome.
FT CHAIN 1..171
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 2"
FT /id="PRO_0000342162"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 135..155
FT /evidence="ECO:0000255"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 171 AA; 19566 MW; 510C6CA5B552D7C0 CRC64;
MADEESSSSS LLSKDLKLPP KTARDIGSVD IKEDEDPFGE ISTDARARQR LVSEGSTTAE
AEEKDLKETC RVAFDKITQY LNGELTASLE DYTLLEQLNN LTTDKYKEMS TMTKSLITTM
EKLDDKYKSL QPYLEQIDRI EDSVSSLEQA AYRLDAYSKK LENKFKRLER R
