ID   BL1S2_XENTR             Reviewed;         147 AA.
AC   Q66KB9;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 2;
DE            Short=BLOC-1 subunit 2;
GN   Name=bloc1s2; ORFNames=TTpA018b22.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO), such as
CC       platelet dense granules and melanosomes. May also play a role in
CC       intracellular vesicle trafficking. As part of a BORC-like complex may
CC       play a role in lysosomes movement and localization at the cell
CC       periphery. Associated with the cytosolic face of lysosomes, this
CC       complex may couple lysosomes to microtubule plus-end-directed kinesin
CC       motor. {ECO:0000250|UniProtKB:Q6QNY1}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1). {ECO:0000250|UniProtKB:Q6QNY1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q6QNY1}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:Q6QNY1}.
CC   -!- SIMILARITY: Belongs to the BLOC1S2 family. {ECO:0000305}.
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DR   EMBL; CR760883; CAJ83190.1; -; mRNA.
DR   EMBL; BC080469; AAH80469.1; -; mRNA.
DR   RefSeq; NP_001008201.1; NM_001008200.1.
DR   RefSeq; XP_012821943.1; XM_012966489.2.
DR   RefSeq; XP_012821944.1; XM_012966490.2.
DR   AlphaFoldDB; Q66KB9; -.
DR   SMR; Q66KB9; -.
DR   STRING; 8364.ENSXETP00000050858; -.
DR   PaxDb; Q66KB9; -.
DR   Ensembl; ENSXETT00000050858; ENSXETP00000050858; ENSXETG00000023568.
DR   GeneID; 493563; -.
DR   KEGG; xtr:493563; -.
DR   CTD; 282991; -.
DR   Xenbase; XB-GENE-967291; bloc1s2.
DR   eggNOG; KOG4559; Eukaryota.
DR   HOGENOM; CLU_110820_0_1_1; -.
DR   InParanoid; Q66KB9; -.
DR   OMA; CSDMFEK; -.
DR   OrthoDB; 1505524at2759; -.
DR   PhylomeDB; Q66KB9; -.
DR   TreeFam; TF313861; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023568; Expressed in liver and 26 other tissues.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR   GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR   InterPro; IPR019269; BLOC1_su2.
DR   PANTHER; PTHR46479; PTHR46479; 1.
DR   Pfam; PF10046; BLOC1_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Lysosome; Membrane;
KW   Reference proteome.
FT   CHAIN           1..147
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 2"
FT                   /id="PRO_0000234547"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          84..132
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   147 AA;  16697 MW;  B50F60C07EEBCF6A CRC64;
     MAEQEGPDKP PLNEQPVAPS ASQDDATVET AEEAVEPPEA DINELCRDMF SKMALYLTGE
     LTTTSEDYKL LENMNKLTSL KYMEMKDIAG NISRNLKDLN KKYASLQPYL EQINQIEEQV
     ASLENAAYKL DAYSKRLEAK FKKLEKR