ID   BL1S3_BOVIN             Reviewed;         200 AA.
AC   A5PJP1;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 3;
DE            Short=BLOC-1 subunit 3;
GN   Name=BLOC1S3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO), such as
CC       platelet dense granules and melanosomes. In concert with the AP-3
CC       complex, the BLOC-1 complex is required to target membrane protein
CC       cargos into vesicles assembled at cell bodies for delivery into
CC       neurites and nerve terminals. The BLOC-1 complex, in association with
CC       SNARE proteins, is also proposed to be involved in neurite extension.
CC       Plays a role in intracellular vesicle trafficking (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4,
CC       BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed
CC       of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6,
CC       DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with
CC       the AP-3 protein complex and membrane protein cargos. Interacts
CC       directly with BLOC1S2. Interacts with BLOC1S4, BLOC1S5 and BLOC1S6 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BLOC1S3 family. {ECO:0000305}.
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DR   EMBL; BC142188; AAI42189.1; -; mRNA.
DR   RefSeq; NP_001092556.1; NM_001099086.1.
DR   RefSeq; XP_003583487.1; XM_003583439.4.
DR   RefSeq; XP_003587321.1; XM_003587273.4.
DR   AlphaFoldDB; A5PJP1; -.
DR   SMR; A5PJP1; -.
DR   STRING; 9913.ENSBTAP00000009293; -.
DR   PaxDb; A5PJP1; -.
DR   PRIDE; A5PJP1; -.
DR   Ensembl; ENSBTAT00000009293; ENSBTAP00000009293; ENSBTAG00000007070.
DR   GeneID; 538539; -.
DR   KEGG; bta:538539; -.
DR   CTD; 388552; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007070; -.
DR   VGNC; VGNC:52182; BLOC1S3.
DR   eggNOG; ENOG502RZCG; Eukaryota.
DR   GeneTree; ENSGT00390000008756; -.
DR   HOGENOM; CLU_116012_0_0_1; -.
DR   InParanoid; A5PJP1; -.
DR   OMA; DIITSCN; -.
DR   OrthoDB; 1289841at2759; -.
DR   TreeFam; TF336303; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000007070; Expressed in retina and 102 other tissues.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
DR   GO; GO:0030133; C:transport vesicle; ISS:UniProtKB.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0035646; P:endosome to melanosome transport; ISS:UniProtKB.
DR   GO; GO:0001654; P:eye development; IEA:Ensembl.
DR   GO; GO:0032438; P:melanosome organization; IEA:Ensembl.
DR   GO; GO:0032402; P:melanosome transport; ISS:UniProtKB.
DR   GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR   GO; GO:0030168; P:platelet activation; IEA:Ensembl.
DR   GO; GO:0060155; P:platelet dense granule organization; IEA:Ensembl.
DR   GO; GO:0032816; P:positive regulation of natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0033299; P:secretion of lysosomal enzymes; IEA:Ensembl.
DR   InterPro; IPR017245; BLOC-1_complex_su-3.
DR   PANTHER; PTHR31974; PTHR31974; 1.
DR   Pfam; PF15753; BLOC1S3; 1.
DR   PIRSF; PIRSF037630; BLOC-1_complex_subunit_3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..200
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 3"
FT                   /id="PRO_0000342164"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         63
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6QNY0"
FT   MOD_RES         65
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6QNY0"
SQ   SEQUENCE   200 AA;  21058 MW;  932143B77799B136 CRC64;
     MESQSRRRRP LRRPETLVQG EAAESDSDLS ASSSEEEELY LGPSGPTRGR PTGLRVAGEA
     AETDSDPEPE PKAAPRDLPP LVVQRETAGE AWAEEEAPAP APARSLLQLR LAESQARLDH
     DVAAAVSGVY RRAGRDVAAL AGRLAAAQAA GLAAAHSVRL ARGDLCALAE RLDIVASCRL
     LPDIRGVPGT EPEQDPGPRA