BL1S3_DROME
ID BL1S3_DROME Reviewed; 144 AA.
AC A8JNV4;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 3;
DE Short=BLOC-1 subunit 3;
GN Name=Blos3 {ECO:0000312|FlyBase:FBgn0085284};
GN ORFNames=CG34255 {ECO:0000312|FlyBase:FBgn0085284};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, AND FUNCTION.
RX PubMed=20015953; DOI=10.1093/hmg/ddp555;
RA Cheli V.T., Daniels R.W., Godoy R., Hoyle D.J., Kandachar V., Starcevic M.,
RA Martinez-Agosto J.A., Poole S., DiAntonio A., Lloyd V.K., Chang H.C.,
RA Krantz D.E., Dell'Angelica E.C.;
RT "Genetic modifiers of abnormal organelle biogenesis in a Drosophila model
RT of BLOC-1 deficiency.";
RL Hum. Mol. Genet. 19:861-878(2010).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in pigment granule biogenesis.
CC {ECO:0000269|PubMed:20015953}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4, Dysb, Muted,
CC Pldn and Snapin. {ECO:0000269|PubMed:20015953}.
CC -!- SIMILARITY: Belongs to the BLOC1S3 family. {ECO:0000305}.
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DR EMBL; AE014296; ABW08567.1; -; Genomic_DNA.
DR RefSeq; NP_001097640.1; NM_001104170.3.
DR AlphaFoldDB; A8JNV4; -.
DR SMR; A8JNV4; -.
DR BioGRID; 624978; 1.
DR STRING; 7227.FBpp0111364; -.
DR PaxDb; A8JNV4; -.
DR EnsemblMetazoa; FBtr0112449; FBpp0111364; FBgn0085284.
DR GeneID; 5740347; -.
DR KEGG; dme:Dmel_CG34255; -.
DR UCSC; CG34255-RA; d. melanogaster.
DR CTD; 5740347; -.
DR FlyBase; FBgn0085284; Blos3.
DR VEuPathDB; VectorBase:FBgn0085284; -.
DR eggNOG; ENOG502SCBJ; Eukaryota.
DR HOGENOM; CLU_1798485_0_0_1; -.
DR InParanoid; A8JNV4; -.
DR OMA; SNFLPHI; -.
DR OrthoDB; 1477753at2759; -.
DR PhylomeDB; A8JNV4; -.
DR BioGRID-ORCS; 5740347; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 5740347; -.
DR PRO; PR:A8JNV4; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0085284; Expressed in brain and 12 other tissues.
DR ExpressionAtlas; A8JNV4; baseline.
DR Genevisible; A8JNV4; DM.
DR GO; GO:0031083; C:BLOC-1 complex; ISS:FlyBase.
DR InterPro; IPR017245; BLOC-1_complex_su-3.
DR PANTHER; PTHR31974; PTHR31974; 1.
DR Pfam; PF15753; BLOC1S3; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..144
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 3"
FT /id="PRO_0000420205"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 102..133
FT /evidence="ECO:0000255"
SQ SEQUENCE 144 AA; 16070 MW; FAE3B9A6D87A36BA CRC64;
MADLVSGEAS ESDEELQEKN KIFAAEISGE ASEEDDEDIY EQGRSSNQVN STASIYRNNL
LQRKLIENNI AIWRSLTAFT RSFVLSASKQ LVTTDQMLIK SQHSLQSAHT SLQQAQKNAQ
DLQNRVADVI TSNFLPHISI QKAT
