ID   BL1S3_PIG               Reviewed;         199 AA.
AC   A5A769;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 3;
DE            Short=BLOC-1 subunit 3;
GN   Name=BLOC1S3;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Okumura N., Matsumoto T., Hamasima N., Uenishi H., Ogawa T., Komatsuda A.,
RA   Fukudome N., Ide H., Suzuki A., Kojima C., Awata T.;
RT   "Sequences and genetic variations of fourty-four porcine coat color related
RT   genes.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO), such as
CC       platelet dense granules and melanosomes. In concert with the AP-3
CC       complex, the BLOC-1 complex is required to target membrane protein
CC       cargos into vesicles assembled at cell bodies for delivery into
CC       neurites and nerve terminals. The BLOC-1 complex, in association with
CC       SNARE proteins, is also proposed to be involved in neurite extension.
CC       Plays a role in intracellular vesicle trafficking (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4,
CC       BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed
CC       of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6,
CC       DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with
CC       the AP-3 protein complex and membrane protein cargos. Interacts
CC       directly with BLOC1S2. Interacts with BLOC1S4, BLOC1S5 and BLOC1S6 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BLOC1S3 family. {ECO:0000305}.
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DR   EMBL; AB271939; BAF62314.1; -; mRNA.
DR   RefSeq; NP_001092056.1; NM_001098586.1.
DR   AlphaFoldDB; A5A769; -.
DR   SMR; A5A769; -.
DR   PeptideAtlas; A5A769; -.
DR   Ensembl; ENSSSCT00025061038; ENSSSCP00025025915; ENSSSCG00025044967.
DR   Ensembl; ENSSSCT00030085207; ENSSSCP00030039255; ENSSSCG00030060981.
DR   Ensembl; ENSSSCT00035094143; ENSSSCP00035039538; ENSSSCG00035069690.
DR   Ensembl; ENSSSCT00040084782; ENSSSCP00040037012; ENSSSCG00040062269.
DR   Ensembl; ENSSSCT00045063826; ENSSSCP00045045045; ENSSSCG00045037037.
DR   Ensembl; ENSSSCT00050066582; ENSSSCP00050028612; ENSSSCG00050048921.
DR   Ensembl; ENSSSCT00055023600; ENSSSCP00055018662; ENSSSCG00055012069.
DR   Ensembl; ENSSSCT00060037966; ENSSSCP00060016144; ENSSSCG00060028062.
DR   Ensembl; ENSSSCT00065001617; ENSSSCP00065000497; ENSSSCG00065001328.
DR   GeneID; 100049671; -.
DR   KEGG; ssc:100049671; -.
DR   CTD; 388552; -.
DR   InParanoid; A5A769; -.
DR   OrthoDB; 1289841at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
DR   GO; GO:0030133; C:transport vesicle; ISS:UniProtKB.
DR   GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0035646; P:endosome to melanosome transport; ISS:UniProtKB.
DR   GO; GO:0032402; P:melanosome transport; ISS:UniProtKB.
DR   GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR   InterPro; IPR017245; BLOC-1_complex_su-3.
DR   PANTHER; PTHR31974; PTHR31974; 1.
DR   Pfam; PF15753; BLOC1S3; 1.
DR   PIRSF; PIRSF037630; BLOC-1_complex_subunit_3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..199
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 3"
FT                   /id="PRO_0000342165"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         62
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6QNY0"
FT   MOD_RES         64
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6QNY0"
SQ   SEQUENCE   199 AA;  20905 MW;  D5D0208E2AF57BA7 CRC64;
     MASQSRRRRP LRRPETMVPG EAAETDSELS ASSEEEELYL GPSGPTRGRP TGLRVAGEAA
     ETDSDTEPEP KAAPRDLPPL VVQRETAGET WGEEETPAPA PALSLLQLRL AESQARLDHD
     VAAAVSGVYR RAGRDVAALA GRLAAAQAAG LAAAHSVRLA RGDLCALAER LDIVAGCRLL
     PDIRGVPGTE PEQDPGPRA