BL1S4_DROME
ID BL1S4_DROME Reviewed; 169 AA.
AC Q9VTC2;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 4;
DE Short=BLOC-1 subunit 4;
DE AltName: Full=Protein cappuccino homolog;
GN Name=Blos4 {ECO:0000312|FlyBase:FBgn0036105};
GN ORFNames=CG14149 {ECO:0000312|FlyBase:FBgn0036105};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION, AND INTERACTION WITH PLDN.
RX PubMed=20015953; DOI=10.1093/hmg/ddp555;
RA Cheli V.T., Daniels R.W., Godoy R., Hoyle D.J., Kandachar V., Starcevic M.,
RA Martinez-Agosto J.A., Poole S., DiAntonio A., Lloyd V.K., Chang H.C.,
RA Krantz D.E., Dell'Angelica E.C.;
RT "Genetic modifiers of abnormal organelle biogenesis in a Drosophila model
RT of BLOC-1 deficiency.";
RL Hum. Mol. Genet. 19:861-878(2010).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in pigment granule biogenesis.
CC {ECO:0000269|PubMed:20015953}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4, Dysb, Muted,
CC Pldn and Snapin. Interacts with Pldn. {ECO:0000269|PubMed:20015953}.
CC -!- INTERACTION:
CC Q9VTC2; Q4V5L1: Dmel\CG15124; NbExp=3; IntAct=EBI-122095, EBI-173665;
CC -!- SIMILARITY: Belongs to the BLOC1S4 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF50130.1; -; Genomic_DNA.
DR EMBL; AY071122; AAL48744.1; -; mRNA.
DR RefSeq; NP_001261689.1; NM_001274760.1.
DR RefSeq; NP_648414.1; NM_140157.3.
DR AlphaFoldDB; Q9VTC2; -.
DR SMR; Q9VTC2; -.
DR BioGRID; 64596; 5.
DR IntAct; Q9VTC2; 8.
DR STRING; 7227.FBpp0075998; -.
DR PaxDb; Q9VTC2; -.
DR DNASU; 39219; -.
DR EnsemblMetazoa; FBtr0076269; FBpp0075998; FBgn0036105.
DR EnsemblMetazoa; FBtr0333403; FBpp0305595; FBgn0036105.
DR GeneID; 39219; -.
DR KEGG; dme:Dmel_CG14149; -.
DR UCSC; CG14149-RA; d. melanogaster.
DR CTD; 39219; -.
DR FlyBase; FBgn0036105; Blos4.
DR VEuPathDB; VectorBase:FBgn0036105; -.
DR eggNOG; ENOG502SAED; Eukaryota.
DR GeneTree; ENSGT00390000006790; -.
DR HOGENOM; CLU_096507_1_0_1; -.
DR InParanoid; Q9VTC2; -.
DR OMA; CTNIDDM; -.
DR OrthoDB; 1592082at2759; -.
DR PhylomeDB; Q9VTC2; -.
DR BioGRID-ORCS; 39219; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39219; -.
DR PRO; PR:Q9VTC2; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036105; Expressed in saliva-secreting gland and 26 other tissues.
DR ExpressionAtlas; Q9VTC2; baseline and differential.
DR Genevisible; Q9VTC2; DM.
DR GO; GO:0031083; C:BLOC-1 complex; ISS:FlyBase.
DR GO; GO:0008057; P:eye pigment granule organization; IMP:UniProtKB.
DR InterPro; IPR024857; Cappuccino.
DR PANTHER; PTHR16230; PTHR16230; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..169
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 4"
FT /id="PRO_0000420196"
SQ SEQUENCE 169 AA; 18851 MW; B4D762F91E6555C2 CRC64;
MQSNIENVSR DYAKILQSAD LEKEINPLCT NIEDMLARLD EFETLLASVR AESNGMMANN
VCSILGFTDS FEQLKARIDG LEQCVGVVSA NLSEVERSVD IAEEELHVTD YSLKGLLLKP
LKAKLSASDT STLSSLPRSN LVEEEYQPVE IYKSDDYFGK SEEENYVAK
