BL1S5_CHICK
ID BL1S5_CHICK Reviewed; 196 AA.
AC Q5ZK77;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 5;
DE Short=BLOC-1 subunit 5;
DE AltName: Full=Protein Muted homolog;
GN Name=BLOC1S5; Synonyms=MUTED; ORFNames=RCJMB04_12k14;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO), such as
CC platelet dense granules and melanosomes. Plays a role in intracellular
CC vesicle trafficking (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex 1 (BLOC-1). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BLOC1S5 family. {ECO:0000305}.
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DR EMBL; AJ720207; CAG31866.1; -; mRNA.
DR RefSeq; NP_001006373.1; NM_001006373.1.
DR AlphaFoldDB; Q5ZK77; -.
DR SMR; Q5ZK77; -.
DR STRING; 9031.ENSGALP00000020823; -.
DR PaxDb; Q5ZK77; -.
DR Ensembl; ENSGALT00000020852; ENSGALP00000020823; ENSGALG00000012782.
DR GeneID; 420866; -.
DR KEGG; gga:420866; -.
DR CTD; 63915; -.
DR VEuPathDB; HostDB:geneid_420866; -.
DR eggNOG; ENOG502S2QH; Eukaryota.
DR GeneTree; ENSGT00390000003564; -.
DR HOGENOM; CLU_110751_1_0_1; -.
DR InParanoid; Q5ZK77; -.
DR OrthoDB; 1593497at2759; -.
DR PhylomeDB; Q5ZK77; -.
DR TreeFam; TF332943; -.
DR PRO; PR:Q5ZK77; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000012782; Expressed in cerebellum and 13 other tissues.
DR ExpressionAtlas; Q5ZK77; baseline and differential.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR GO; GO:0048490; P:anterograde synaptic vesicle transport; IEA:Ensembl.
DR GO; GO:0035646; P:endosome to melanosome transport; IEA:Ensembl.
DR GO; GO:0032402; P:melanosome transport; IEA:Ensembl.
DR GO; GO:0032474; P:otolith morphogenesis; IEA:Ensembl.
DR GO; GO:0050942; P:positive regulation of pigment cell differentiation; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:Ensembl.
DR InterPro; IPR017243; Bloc1s5.
DR PANTHER; PTHR31784; PTHR31784; 1.
DR Pfam; PF14942; Muted; 1.
DR PIRSF; PIRSF037610; BLOC-1_complex_muted_subunit; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..196
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 5"
FT /id="PRO_0000330835"
FT COILED 103..196
FT /evidence="ECO:0000255"
SQ SEQUENCE 196 AA; 22662 MW; 15E934F02E0F0445 CRC64;
MSGAGPASPG RSGSALPLPL PLSLSLTGDR KREVPAAGTL LQPIIKDVGE IYSRLLDHRP
VIQGEIRYFV KEFEEKRGLR ELRVLENLKK TIFETNEDIL PKCKQSMHDN LNEVLQRLQA
ANDTIHKLQE KEHEKRKIQA DKLMAGEEKR IAQQETFLQE QQSKREEVDE EHRKAMERLK
EQYSEMEKEL AKYVSF
