BL1S5_DROME
ID BL1S5_DROME Reviewed; 160 AA.
AC Q0KI28;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 5;
DE Short=BLOC-1 subunit 5;
DE AltName: Full=Protein Muted;
GN Name=Muted {ECO:0000312|FlyBase:FBgn0083967};
GN ORFNames=CG34131 {ECO:0000312|FlyBase:FBgn0083967};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, AND FUNCTION.
RX PubMed=20015953; DOI=10.1093/hmg/ddp555;
RA Cheli V.T., Daniels R.W., Godoy R., Hoyle D.J., Kandachar V., Starcevic M.,
RA Martinez-Agosto J.A., Poole S., DiAntonio A., Lloyd V.K., Chang H.C.,
RA Krantz D.E., Dell'Angelica E.C.;
RT "Genetic modifiers of abnormal organelle biogenesis in a Drosophila model
RT of BLOC-1 deficiency.";
RL Hum. Mol. Genet. 19:861-878(2010).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in pigment granule biogenesis.
CC {ECO:0000269|PubMed:20015953}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4, Dysb, Muted,
CC Pldn and Snapin. {ECO:0000269|PubMed:20015953}.
CC -!- SIMILARITY: Belongs to the BLOC1S5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014297; ABI31195.1; -; Genomic_DNA.
DR RefSeq; NP_001036744.1; NM_001043279.1.
DR RefSeq; NP_001287464.1; NM_001300535.1.
DR AlphaFoldDB; Q0KI28; -.
DR SMR; Q0KI28; -.
DR BioGRID; 607089; 1.
DR STRING; 7227.FBpp0110178; -.
DR PaxDb; Q0KI28; -.
DR EnsemblMetazoa; FBtr0110878; FBpp0110178; FBgn0083967.
DR EnsemblMetazoa; FBtr0344526; FBpp0310877; FBgn0083967.
DR GeneID; 4379860; -.
DR KEGG; dme:Dmel_CG34131; -.
DR UCSC; CG34131-RA; d. melanogaster.
DR CTD; 4379860; -.
DR FlyBase; FBgn0083967; Muted.
DR VEuPathDB; VectorBase:FBgn0083967; -.
DR eggNOG; ENOG502S5R8; Eukaryota.
DR GeneTree; ENSGT00390000016974; -.
DR HOGENOM; CLU_110751_2_0_1; -.
DR InParanoid; Q0KI28; -.
DR OMA; IQWEDFM; -.
DR PhylomeDB; Q0KI28; -.
DR BioGRID-ORCS; 4379860; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 4379860; -.
DR PRO; PR:Q0KI28; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0083967; Expressed in gastrula and 28 other tissues.
DR Genevisible; Q0KI28; DM.
DR GO; GO:0031083; C:BLOC-1 complex; ISS:FlyBase.
DR GO; GO:0030133; C:transport vesicle; IEA:InterPro.
DR InterPro; IPR017243; Bloc1s5.
DR PANTHER; PTHR31784; PTHR31784; 1.
DR Pfam; PF14942; Muted; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..160
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 5"
FT /id="PRO_0000420198"
SQ SEQUENCE 160 AA; 18327 MW; E788985E5919C63E CRC64;
MKIMISQVGR ELYKVPLRIL DHRVFVNGEI EAFLENFEVR RNDSEVEKLF QVTETVGSLK
YDLSRCSATG RGSGAENLAQ LDTEVSHLLD GVNALLAKAK VERTASTQLQ EARLAREQRR
AEFLTNLEHG YRRIENSFEE KEEEIAELYS DLQLKLNIAK
