ID   BL1S5_PIG               Reviewed;         191 AA.
AC   A5A777;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 5;
DE            Short=BLOC-1 subunit 5;
DE   AltName: Full=Protein Muted homolog;
GN   Name=BLOC1S5; Synonyms=MUTED;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Landrace;
RA   Okumura N., Matsumoto T., Hamasima N., Uenishi H., Ogawa T., Komatsuda A.,
RA   Fukudome N., Ide H., Suzuki A., Kojima C., Awata T.;
RT   "Sequences and genetic variations of fourty-four porcine coat color related
RT   genes.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO), such as
CC       platelet dense granules and melanosomes. In concert with the AP-3
CC       complex, the BLOC-1 complex is required to target membrane protein
CC       cargos into vesicles assembled at cell bodies for delivery into
CC       neurites and nerve terminals. The BLOC-1 complex, in association with
CC       SNARE proteins, is also proposed to be involved in neurite extension.
CC       Plays a role in intracellular vesicle trafficking (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4,
CC       BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed
CC       of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6,
CC       DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with
CC       the AP-3 protein complex and membrane protein cargos. Interacts with
CC       BLOC1S4, BLOC1S6, DTNBP1/BLOC1S7 and PI4K2A (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BLOC1S5 family. {ECO:0000305}.
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DR   EMBL; AB271947; BAF62322.1; -; mRNA.
DR   RefSeq; NP_001092061.1; NM_001098591.1.
DR   AlphaFoldDB; A5A777; -.
DR   SMR; A5A777; -.
DR   STRING; 9823.ENSSSCP00000022287; -.
DR   PaxDb; A5A777; -.
DR   Ensembl; ENSSSCT00005056612; ENSSSCP00005034846; ENSSSCG00005035474.
DR   GeneID; 100049677; -.
DR   KEGG; ssc:100049677; -.
DR   CTD; 63915; -.
DR   eggNOG; ENOG502S2QH; Eukaryota.
DR   InParanoid; A5A777; -.
DR   OrthoDB; 1593497at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
DR   GO; GO:0030133; C:transport vesicle; ISS:UniProtKB.
DR   GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0035646; P:endosome to melanosome transport; ISS:UniProtKB.
DR   GO; GO:0032402; P:melanosome transport; ISS:UniProtKB.
DR   GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR   GO; GO:0050942; P:positive regulation of pigment cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR017243; Bloc1s5.
DR   PANTHER; PTHR31784; PTHR31784; 1.
DR   Pfam; PF14942; Muted; 1.
DR   PIRSF; PIRSF037610; BLOC-1_complex_muted_subunit; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDH9"
FT   CHAIN           2..191
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 5"
FT                   /id="PRO_0000330834"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          160..191
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDH9"
SQ   SEQUENCE   191 AA;  21767 MW;  87C7D031D20576C1 CRC64;
     MSGGGTETPT GCEAPSGGGG GGGRKRDSLG TTSSPAHLII KDLGEIHSRL LDHRPVIQGE
     TRYFVKEFEE KRGLREMRAL ENLKNMIHET NEHTLPTCTE TMEDSLSHVL QRLQAATASV
     CRLQQREQER KKVHNDHLIA SEKQHIMQWE DFMKEQHSKQ ADVDEEHRKA MEKLKEQYAE
     MEKDLAKFST F