BL1S5_RAT
ID BL1S5_RAT Reviewed; 187 AA.
AC B2GV52;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 5;
DE Short=BLOC-1 subunit 5;
DE AltName: Full=Protein Muted homolog;
GN Name=Bloc1s5; Synonyms=Mu, Muted;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16760431; DOI=10.1091/mbc.e06-02-0103;
RA Salazar G., Craige B., Styers M.L., Newell-Litwa K.A., Doucette M.M.,
RA Wainer B.H., Falcon-Perez J.M., Dell'Angelica E.C., Peden A.A., Werner E.,
RA Faundez V.;
RT "BLOC-1 complex deficiency alters the targeting of adaptor protein complex-
RT 3 cargoes.";
RL Mol. Biol. Cell 17:4014-4026(2006).
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO), such as
CC platelet dense granules and melanosomes. In concert with the AP-3
CC complex, the BLOC-1 complex is required to target membrane protein
CC cargos into vesicles assembled at cell bodies for delivery into
CC neurites and nerve terminals. The BLOC-1 complex, in association with
CC SNARE proteins, is also proposed to be involved in neurite extension.
CC Plays a role in intracellular vesicle trafficking (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3,
CC BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-
CC 1 complex associates with the AP-3 protein complex and membrane protein
CC cargos. Interacts with BLOC1S4, BLOC1S6, DTNBP1/BLOC1S7 and PI4K2A (By
CC similarity). Component of the biogenesis of lysosome-related organelles
CC complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4,
CC BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. {ECO:0000250,
CC ECO:0000269|PubMed:16760431}.
CC -!- SIMILARITY: Belongs to the BLOC1S5 family. {ECO:0000305}.
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DR EMBL; CH473977; EDL98252.1; -; Genomic_DNA.
DR EMBL; BC166529; AAI66529.1; -; mRNA.
DR RefSeq; NP_001100817.1; NM_001107347.1.
DR AlphaFoldDB; B2GV52; -.
DR SMR; B2GV52; -.
DR STRING; 10116.ENSRNOP00000022108; -.
DR jPOST; B2GV52; -.
DR PaxDb; B2GV52; -.
DR PeptideAtlas; B2GV52; -.
DR Ensembl; ENSRNOT00000022108; ENSRNOP00000022108; ENSRNOG00000016497.
DR GeneID; 306868; -.
DR KEGG; rno:306868; -.
DR UCSC; RGD:1306846; rat.
DR CTD; 63915; -.
DR RGD; 1306846; Bloc1s5.
DR eggNOG; ENOG502S2QH; Eukaryota.
DR GeneTree; ENSGT00390000016974; -.
DR HOGENOM; CLU_110751_0_0_1; -.
DR InParanoid; B2GV52; -.
DR OMA; IQWEDFM; -.
DR OrthoDB; 1593497at2759; -.
DR PhylomeDB; B2GV52; -.
DR TreeFam; TF332943; -.
DR PRO; PR:B2GV52; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Proteomes; UP000234681; Chromosome 17.
DR Bgee; ENSRNOG00000016497; Expressed in heart and 20 other tissues.
DR Genevisible; B2GV52; RN.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
DR GO; GO:0030133; C:transport vesicle; ISO:RGD.
DR GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR GO; GO:0048066; P:developmental pigmentation; ISO:RGD.
DR GO; GO:0035646; P:endosome to melanosome transport; ISO:RGD.
DR GO; GO:0010467; P:gene expression; ISO:RGD.
DR GO; GO:0032402; P:melanosome transport; ISO:RGD.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0032474; P:otolith morphogenesis; ISO:RGD.
DR GO; GO:0050942; P:positive regulation of pigment cell differentiation; ISO:RGD.
DR GO; GO:0016192; P:vesicle-mediated transport; ISO:RGD.
DR InterPro; IPR017243; Bloc1s5.
DR PANTHER; PTHR31784; PTHR31784; 1.
DR Pfam; PF14942; Muted; 1.
DR PIRSF; PIRSF037610; BLOC-1_complex_muted_subunit; 1.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8TDH9"
FT CHAIN 2..187
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 5"
FT /id="PRO_0000420189"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TDH9"
SQ SEQUENCE 187 AA; 21539 MW; CC2A44934E5A08F0 CRC64;
MSGGGTETPV ACEAAQGGGG KKRDSLGTAG AAHLIIKDLG EIHSRLLDHR PVTQGEIRYF
VKEFEEKRGL RELRVLENLK NMIQETNERM LPKCRETMQG GLEETLQRLQ AATDSIHRLQ
QREQERKKVI NDHLTASEKQ RMLQWEEFLR GQPQRRAEVD AEHRKAMERL REQYAAMEKD
LAKFSTF
