ID   BL1S5_XENLA             Reviewed;         188 AA.
AC   A1L3H4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 5;
DE            Short=BLOC-1 subunit 5;
DE   AltName: Full=Protein Muted homolog;
GN   Name=bloc1s5; Synonyms=muted;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO), such as
CC       platelet dense granules and melanosomes. Plays a role in intracellular
CC       vesicle trafficking (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BLOC1S5 family. {ECO:0000305}.
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DR   EMBL; BC130100; AAI30101.1; -; mRNA.
DR   RefSeq; NP_001091226.1; NM_001097757.1.
DR   AlphaFoldDB; A1L3H4; -.
DR   SMR; A1L3H4; -.
DR   BioGRID; 674286; 1.
DR   IntAct; A1L3H4; 1.
DR   DNASU; 100037008; -.
DR   GeneID; 100037008; -.
DR   KEGG; xla:100037008; -.
DR   CTD; 100037008; -.
DR   Xenbase; XB-GENE-919989; bloc1s5.L.
DR   OMA; IQWEDFM; -.
DR   OrthoDB; 1593497at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 100037008; Expressed in blastula and 19 other tissues.
DR   GO; GO:0031083; C:BLOC-1 complex; IEA:InterPro.
DR   GO; GO:0030133; C:transport vesicle; IEA:InterPro.
DR   InterPro; IPR017243; Bloc1s5.
DR   PANTHER; PTHR31784; PTHR31784; 1.
DR   Pfam; PF14942; Muted; 1.
DR   PIRSF; PIRSF037610; BLOC-1_complex_muted_subunit; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..188
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit 5"
FT                   /id="PRO_0000330836"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          101..183
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   188 AA;  21647 MW;  14DCD44A9E12CDBF CRC64;
     MSSSSSSSSP VKSTGSPFIQ SLKPRESLAS MGSATQLVIK DIGEIHSRLL DHRPVIQGET
     RYFIKEFEEK RGLREMRVLE NLRNSISETN EHALPKCTSV MQDQLASVLK KLETANHTIH
     RLQQRELENA KRSASKAGEE KMRAHWEPVM KEQEQKRQTV DEEHRKAVMR LKEQYVTMDK
     ELSKQISF