BL1S6_BOVIN
ID BL1S6_BOVIN Reviewed; 172 AA.
AC Q08DU8; F1MY65;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 6;
DE Short=BLOC-1 subunit 6;
DE AltName: Full=Pallid protein homolog;
DE AltName: Full=Pallidin;
GN Name=BLOC1S6; Synonyms=PA, PLDN;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, AND INTERACTION WITH SNAP25; SNAP47
RP AND STX12.
RX PubMed=19546860; DOI=10.1038/mp.2009.58;
RA Ghiani C.A., Starcevic M., Rodriguez-Fernandez I.A., Nazarian R.,
RA Cheli V.T., Chan L.N., Malvar J.S., de Vellis J., Sabatti C.,
RA Dell'Angelica E.C.;
RT "The dysbindin-containing complex (BLOC-1) in brain: developmental
RT regulation, interaction with SNARE proteins and role in neurite
RT outgrowth.";
RL Mol. Psychiatry 15:204-215(2010).
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO), such as
CC platelet dense granules and melanosomes. In concert with the AP-3
CC complex, the BLOC-1 complex is required to target membrane protein
CC cargos into vesicles assembled at cell bodies for delivery into
CC neurites and nerve terminals. The BLOC-1 complex, in association with
CC SNARE proteins, is also proposed to be involved in neurite extension.
CC May play a role in intracellular vesicle trafficking, particularly in
CC the vesicle-docking and fusion process (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Octamer composed of one copy each BLOC1S1, BLOC1S2,
CC BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8.
CC The BLOC-1 complex associates with the AP-3 protein complex and
CC membrane protein cargos. Interacts with BLOC1S4, BLOC1S5,
CC DTNBP1/BLOC1S7, F-actin (By similarity). Component of the biogenesis of
CC lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1,
CC BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and
CC SNAPIN/BLOC1S8. Interacts with SNAP25, SNAP47 and STX12. {ECO:0000250,
CC ECO:0000269|PubMed:19546860}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UL45}.
CC Membrane {ECO:0000250|UniProtKB:Q9UL45}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9UL45}. Note=It can exist as a soluble protein
CC as well as a peripheral membrane protein.
CC {ECO:0000250|UniProtKB:Q9UL45}.
CC -!- SIMILARITY: Belongs to the BLOC1S6 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BT030681; ABS44997.1; -; mRNA.
DR EMBL; DAAA02029167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC123557; AAI23558.1; -; mRNA.
DR RefSeq; NP_001069793.1; NM_001076325.1.
DR AlphaFoldDB; Q08DU8; -.
DR SMR; Q08DU8; -.
DR STRING; 9913.ENSBTAP00000016245; -.
DR PaxDb; Q08DU8; -.
DR PRIDE; Q08DU8; -.
DR Ensembl; ENSBTAT00000016245; ENSBTAP00000016245; ENSBTAG00000012250.
DR GeneID; 614408; -.
DR KEGG; bta:614408; -.
DR CTD; 26258; -.
DR VEuPathDB; HostDB:ENSBTAG00000012250; -.
DR VGNC; VGNC:26509; BLOC1S6.
DR eggNOG; ENOG502RZNC; Eukaryota.
DR GeneTree; ENSGT00510000047812; -.
DR HOGENOM; CLU_115118_1_0_1; -.
DR InParanoid; Q08DU8; -.
DR OMA; MMSDVKR; -.
DR OrthoDB; 1509390at2759; -.
DR TreeFam; TF325188; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000012250; Expressed in thyroid gland and 104 other tissues.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:0031201; C:SNARE complex; IEA:Ensembl.
DR GO; GO:0030133; C:transport vesicle; ISS:UniProtKB.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR GO; GO:0007596; P:blood coagulation; IEA:Ensembl.
DR GO; GO:0035646; P:endosome to melanosome transport; ISS:UniProtKB.
DR GO; GO:0046907; P:intracellular transport; IBA:GO_Central.
DR GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
DR GO; GO:0032402; P:melanosome transport; ISS:UniProtKB.
DR GO; GO:0061025; P:membrane fusion; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0032816; P:positive regulation of natural killer cell activation; IEA:Ensembl.
DR GO; GO:0050942; P:positive regulation of pigment cell differentiation; ISS:UniProtKB.
DR GO; GO:0033299; P:secretion of lysosomal enzymes; IEA:Ensembl.
DR InterPro; IPR017242; BLOC-1_pallidin.
DR InterPro; IPR028119; Snapin/Pallidin/Snn1.
DR Pfam; PF14712; Snapin_Pallidin; 1.
DR PIRSF; PIRSF037609; BLOC-1_complex_pallidin; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Membrane; Reference proteome.
FT CHAIN 1..172
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit 6"
FT /id="PRO_0000420190"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 125..167
FT /evidence="ECO:0000255"
FT COMPBIAS 140..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 172 AA; 19546 MW; 62BA292D96B7A964 CRC64;
MSVPGPPSPD GVLAGPPEGL EAGDLTPGLS DTSPDEGLIE DLTIEDKAVE QLAEGLLSHY
LPDLQRSKQA LQELTQNQVV LLDTLEQEIS KFKECHSMLD INALFTEAKH YHAKLVNIRK
EMLMLHEKTS KLKKRALKLQ QKRQKEELER EQQREKEFER EKQLTAKPAK RT
